Contra-indicated in patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF except for the treatment of life-threatening or other serious infections.
- TRADE NAMES: Isox; Itranax; Onmel (Merz); Sporacid; Sporal; Sporanox (Janssen)
- INDICATIONS: Onychomycosis, deep mycoses, oropharyngeal candidiasis (oral solution only)
- CLASS: Antifungal / antimycotic, Antifungal; triazole, Antimicrobial, CYP3A4 inhibitor
- HALF-LIFE: 21 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Abiraterone, Acalabrutinib, Afatinib, Alfentanil, Alfuzosin, Aliskiren, Alprazolam, Amphotericin B, Amprenavir, Anisindione, Antacids, Aprepitant, Aripiprazole, Artemether/Lumefantrine, Astemizole, Atazanavir, Atorvastatin, Avanafil, Avapritinib, Boceprevir, Bosentan, Brigatinib, Budesonide, Buspirone, Busulfan, Cabazitaxel, Cabozantinib, Calcifediol, Calcium channel blockers, Capmatinib, Carbamazepine, Cerivastatin, Ciclesonide, Cilostazol, Cimetidine, Cinacalcet, Cisapride, Clarithromycin, Clopidogrel, Clorazepate, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Alafenamide, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Cobimetinib, Colchicine, Conivaptan, Copanlisib, Corticosteroids, Coumarins, Crizotinib, Cyclophosphamide, Cyclosporine, Cyproterone, Dabigatran, Darifenacin, Dasatinib, Dexamethasone, Diazepam, Dicumarol, Didanosine, Digoxin, Dihydroergotamine, Dihydropyridines, Disopyramide, Docetaxel, Dofetilide, Dronedarone, Efavirenz, Eletriptan, Enzalutamide, Eplerenone, Ergotamine, Erlotinib, Erythromycin, Estradiol, Ethotoin, Everolimus, Felodipine, Fentanyl, Fesoterodine, Flibanserin, Fluticasone Propionate, Fosamprenavir, Fosphenytoin, Gefitinib, Grapefruit Juice, Halofantrine, Haloperidol, Histamine H2-antagonists, HMG-CoA reductase inhibitors, Ibrexafungerp, Ibrutinib, Iloperidone, Imatinib, Indinavir, Infigratinib, Irinotecan, Isoniazid, Ivabradine, Ixabepilone, Lapatinib, Lemborexant, Lercanidipine, Levomethadyl, Lomitapide, Lopinavir, Lovastatin, Lumateperone, Lurasidone, Mephenytoin, Methadone, Methylergonovine, Methylprednisolone, Methysergide, Micafungin, Midazolam(oral), Midostaurin, Mifepristone, Mizolastine, Naldemedine, Neratinib, Nevirapine, Nilotinib, Nisoldipine, Olaparib, Omeprazole, Oral hypoglycemics, Osimertinib, Paclitaxel, Palbociclib, Paliperidone, Pantoprazole, Pazopanib, Pemigatinib, Phenobarbital, Phenytoin, Pimavanserin, Pimecrolimus, Pimozide, Ponatinib, Pralsetinib, Prednisolone, Prednisone, Proton pump inhibitors, Quetiapine, Quinidine, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Ribociclib, Rifabutin, Rifampin, Rilpivirine, Rimegepant, Rimonabant, Ripretinib, Ritonavir, Rivaroxaban, Romidepsin, Ruxolitinib, Saquinavir, Selpercatinib, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Solifenacin, Sonidegib, Sotorasib, Sunitinib, Tacrolimus, Tadalafil, Talazoparib, Telaprevir, Telithromycin, Temsirolimus, Terfenadine, Tezacaftor/Ivacaftor, Ticagrelor, Tolterodine, Tolvaptan, Triamcinolone, Triazolam, Trimetrexate, Tucatinib, Ubrogepant, Ulipristal, Valbenazine, Vardenafil, Vemurafenib, Venetoclax, Vinblastine, Vincristine, Vinflunine, Vinorelbine, Voclosporin, Vorapaxar, Warfarin
- See adverse reactions attributed to class:
CONGESTIVE HEART FAILURE, CARDIAC EFFECTS AND DRUG INTERACTIONS
See full prescribing information for complete boxed warning.
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Page last updated 09/21/2024
