Contra-indicated in opioid non-tolerant patients, and for the management of acute or postoperative pain including headache/migraines and dental pain.
- TRADE NAMES: Abstral; Actiq (Cephalon); Beatryl; Duragesic (Janssen); Fentanest; Leptanal; Sublimaze
- INDICATIONS: Chronic pain
- CLASS: Analgesic; opioid, Anesthetic
- HALF-LIFE: ~7 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Amiodarone, Amprenavir, Aprepitant, Atazanavir, Ceritinib, Cimetidine, Conivaptan, Crizotinib, Darunavir, Dasatinib, Delavirdine, Desipramine, Efavirenz, Eluxadoline, Enzalutamide, Indinavir, Itraconazole, Ketoconazole, Lapatinib, Letermovir, Lopinavir, Mifepristone, Nelfinavir, Nevirapine, Nifedipine, Osimertinib, Ranitidine, Ribociclib, Rifapentine, Ritonavir, Saquinavir, Telithromycin, Voriconazole
- See adverse reactions attributed to class:
ADDICTION, ABUSE, and MISUSE; LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL EXPOSURE; NEONATAL OPIOID WITHDRAWAL SYNDROME; CYTOCHROME P450 3A4 INTERACTION.
EXPOSURE TO HEAT (for topical patches)
See full prescribing information for complete boxed warning.
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Page last updated 03/21/2025
