About the database

This unique website allows you to search the profiles of over 1750 generic and trade name FDA-approved drugs (with herbals, supplements, and other substances used in medical procedures, such as toxins and fillers). It also provides nearly 150,000 peer-reviewed reports of the adverse reactions that link directly to PubMed. The database is updated on a continuous basis with the latest developments in the field, including additional new drugs and new references, so our subscribers can stay abreast of the rapid advances in medical therapy and have rapid access to potentially vital safety data for their patients.

There are various search options to ensure you get to the information you want as quickly as possible:

  • Drugs
  • Adverse reaction
  • Drug class
  • Herbal
  • Reaction category
  • Company
  • Indications

Each drug profile will provide you with a wealth of essential information, including:

  • Synonyms 
  • Trade names 
  • Pharmaceutical company/companies 
  • Class of drug
  • Indications
  • Half-life 
  • Drug-drug interactions 
  • Pregnancy category
  • Any adverse reactions attributed to the class of drug
  • Any clinical note on use
  • Any “Black box” warning required by the FDA
  • Adverse reactions, with a colored box for incidence (where reported) and a colored flag for seriousness (corresponding to Grades 3, 4, and 5 in the Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0, 2017)

Adverse reactions are categorized by skin, hair, nails, mucosal, cardiovascular, central nervous system, neuromuscular/skeletal, respiratory, gastrointestinal, endocrine/metabolic, hematologic, renal, genitourinary, otic, ocular, local and other. 

There are links to drug reviews, where available; to compare each drug’s reaction profile with that of up to three others; to explore the Indication (with photographs of the adverse reaction, if available) and any other drugs that may cause it; to save a search for later retrieval; and to watch a drug and receive a weekly email alert of additions to the drug profile.

Pediatric patients are defined as those up to 18 and geriatric patients as those over 75 years of age.

The database was originated by Jerome Z. Litt from his annual Drug Eruptions and Reactions Manuals; it is now edited by Neil H. Shear.