Protease inhibitors cause dyslipidemia which includes elevated triglycerides and cholesterol and redistribution of body fat centrally to produce the so-called 'protease paunch', breast enlargement, facial atrophy, and 'buffalo hump'
- TRADE NAME: Invirase (Roche)
- INDICATIONS: Advanced HIV infection
- CLASS: Antiretroviral, CYP3A4 inhibitor, HIV-1 protease inhibitor
- HALF-LIFE: 12 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Abiraterone, Afatinib, Alprazolam, Amitriptyline, Amprenavir, Astemizole, Atazanavir, Atorvastatin, Avanafil, Brigatinib, Cabazitaxel, Cabozantinib, Calcifediol, Clindamycin, Clozapine, Copanlisib, Crizotinib, Darifenacin, Darunavir, Dasatinib, Delavirdine, Dihydroergotamine, Dronedarone, Efavirenz, Elbasvir & Grazoprevir, Eluxadoline, Eplerenone, Ergot derivatives, Erlotinib, Everolimus, Fentanyl, Fesoterodine, Flibanserin, Fluticasone Propionate, Itraconazole, Ixabepilone, Ketoconazole, Lapatinib, Levomepromazine, Lomitapide, Lopinavir, Maraviroc, Methysergide, Midazolam, Midostaurin, Mifepristone, Naldemedine, Nelfinavir, Neratinib, Olaparib, Omeprazole, Paclitaxel, Palbociclib, Pantoprazole, Pazopanib, Pentamidine, Phenytoin, Pimozide, Ponatinib, Quinine, Ribociclib, Rifampin, Rilpivirine, Ritonavir, Rivaroxaban, Romidepsin, Rosuvastatin, Ruxolitinib, Sildenafil, Simeprevir, Simvastatin, Solifenacin, Sonidegib, St John's Wort, Sunitinib, Tadalafil, Telithromycin, Temsirolimus, Ticagrelor, Tipranavir, Tolvaptan, Vardenafil, Vemurafenib, Viloxazine, Vorapaxar, Voriconazole
- See adverse reactions attributed to class:
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Page last updated 07/31/2023
