Mifepristone
- TRADE NAMES: Korlym (Corcept); Mifeprex (Danco)
- INDICATIONS: Medical termination of intrauterine pregnancy (Mifeprex); Cushing's syndrome in patients with Type II diabetes (Korlym)
- CLASS: Corticosteroid antagonist, CYP3A4 inhibitor, Progestogen antagonist
- HALF-LIFE: 85 hours
Amprenavir, Aprepitant, Atazanavir, Boceprevir, Bupropion, Carbamazepine, Ciclesonide, Ciprofloxacin, Clarithromycin, Conivaptan, Cyclosporine, Darunavir, Dihydroergotamine, Diltiazem, Efavirenz, Ergotamine, Erythromycin, Fentanyl, Fluconazole, Fluvastatin, Fosamprenavir, Grapefruit Juice, Imatinib, Indinavir, Itraconazole, Lopinavir, Lovastatin, Mibefradil, Nefazodone, Nelfinavir, NSAIDs, Oral Contraceptives, Phenobarbital, Phenytoin, Pimozide, Posaconazole, Quinidine, Repaglinide, Rifabutin, Rifampin, Rifapentine, Ritonavir, Ritonavir, Saquinavir, Simvastatin, Sirolimus, St John's Wort, Tacrolimus, Telaprevir, Telithromycin, Tenoxicam, Triamcinolone, Verapamil, Voriconazole, Warfarin
PREGNANCY CATEGORY: X
Contra-indicated in pregnancy, with concurrent use of simvastatin or lovastatin and CYP3A substrates with narrow therapeutic range or long-term corticosteroid use, and in women with a history of unexplained vaginal bleeding or with endometrial hyperplasia with atypia or endometrial carcinoma.
See full prescribing information for complete boxed warning.
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Page last updated 07/31/2023
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
