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- TRADE NAME: Viracept (ViiV)
- INDICATIONS: HIV infection
- CLASS: Antiretroviral, Covid-19 putative drug, CYP3A4 inhibitor, HIV-1 protease inhibitor
- HALF-LIFE: 3.5–5 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Abiraterone, Afatinib, Alfuzosin, Amiodarone, Amprenavir, Aripiprazole, Artemether/Lumefantrine, Atorvastatin, Avanafil, Barbiturates, Benzodiazepines, Brigatinib, Cabazitaxel, Cabozantinib, Calcifediol, Carbamazepine, Chlordiazepoxide, Ciclesonide, Cisapride, Clonazepam, Clorazepate, Copanlisib, Crizotinib, Cyclosporine, Darifenacin, Dasatinib, Delavirdine, Diazepam, Dihydroergotamine, Eletriptan, Eplerenone, Ergot alkaloids, Ergotamine, Erlotinib, Estrogens, Eszopiclone, Etravirine, Eucalyptus, Everolimus, Fentanyl, Fesoterodine, Flibanserin, Flurazepam, Fluticasone Propionate, Indinavir, Ivabradine, Ixabepilone, Lapatinib, Lomitapide, Lopinavir, Lorazepam, Lovastatin, Lumateperone, Maraviroc, Methadone, Methylergonovine, Methysergide, Midazolam, Midostaurin, Mifepristone, Neratinib, Olaparib, Omeprazole, Oral Contraceptives, Oxazepam, Paclitaxel, Palbociclib, Pantoprazole, Pazopanib, Phenytoin, Pimozide, Ponatinib, Primidone, Progestogens, Quazepam, Quinidine, Quinine, Ranolazine, Rifabutin, Rifampin, Rilpivirine, Ritonavir, Rivaroxaban, Romidepsin, Rosuvastatin, Ruxolitinib, Saquinavir, Sildenafil, Simeprevir, Simvastatin, Solifenacin, St John's Wort, Sunitinib, Tacrolimus, Tadalafil, Telithromycin, Temazepam, Temsirolimus, Ticagrelor, Tolterodine, Tolvaptan, Triazolam, Vardenafil, Vemurafenib, Vorapaxar
- See adverse reactions attributed to class:
Investigated for treating COVID-19.
Protease inhibitors cause dyslipidemia which includes elevated triglycerides and cholesterol and redistribution of body fat centrally to produce the so-called 'protease paunch', breast enlargement, facial atrophy, and 'buffalo hump'
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Page last updated 07/31/2023
