Nelfinavir drug interactions | Litt's Drug Eruption and Reaction Database

Nelfinavir comment watch save

TRADE NAME: Viracept (ViiV)
INDICATIONS: HIV infection
CLASS: Antiretroviral, Covid-19 putative drug, CYP3A4 inhibitor, HIV-1 protease inhibitor
HALF-LIFE: 3.5–5 hours

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Abiraterone, Afatinib, Alfuzosin, Amiodarone, Amprenavir, Aripiprazole, Artemether/Lumefantrine, Atorvastatin, Avanafil, Barbiturates, Benzodiazepines, Brigatinib, Cabazitaxel, Cabozantinib, Calcifediol, Carbamazepine, Chlordiazepoxide, Ciclesonide, Cisapride, Clonazepam, Clorazepate, Copanlisib, Crizotinib, Cyclosporine, Darifenacin, Dasatinib, Delavirdine, Diazepam, Dihydroergotamine, Eletriptan, Eplerenone, Ergot alkaloids, Ergotamine, Erlotinib, Estrogens, Eszopiclone, Etravirine, Eucalyptus, Everolimus, Fentanyl, Fesoterodine, Flibanserin, Flurazepam, Fluticasone Propionate, Indinavir, Ivabradine, Ixabepilone, Lapatinib, Lomitapide, Lopinavir, Lorazepam, Lovastatin, Lumateperone, Maraviroc, Methadone, Methylergonovine, Methysergide, Midazolam, Midostaurin, Mifepristone, Neratinib, Olaparib, Omeprazole, Oral Contraceptives, Oxazepam, Paclitaxel, Palbociclib, Pantoprazole, Pazopanib, Phenytoin, Pimozide, Ponatinib, Primidone, Progestogens, Quazepam, Quinidine, Quinine, Ranolazine, Rifabutin, Rifampin, Rilpivirine, Ritonavir, Rivaroxaban, Romidepsin, Rosuvastatin, Ruxolitinib, Saquinavir, Sildenafil, Simeprevir, Simvastatin, Solifenacin, St John's Wort, Sunitinib, Tacrolimus, Tadalafil, Telithromycin, Temazepam, Temsirolimus, Ticagrelor, Tolterodine, Tolvaptan, Triazolam, Vardenafil, Vemurafenib, Vorapaxar

See adverse reactions attributed to class:
Antiretroviral
Covid-19 putative drug
HIV-1 protease inhibitor

Investigated for treating COVID-19.

Protease inhibitors cause dyslipidemia which includes elevated triglycerides and cholesterol and redistribution of body fat centrally to produce the so-called 'protease paunch', breast enlargement, facial atrophy, and 'buffalo hump'

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Page last updated 07/31/2023

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Incidence

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Seriousness

Hospitalization possible
Life threatening
Fatal

Warnings in other populations

Breast feeding

Geriatric

Pediatric