Methadone
- TRADE NAMES: Dolophine (Roxane); Eptadone; L-Polamidon; Mephenon; Metadon; Methadose (Mallinckrodt)
- INDICATIONS: Pain, narcotic addiction
- CLASS: Opiate agonist
- HALF-LIFE: 15–25 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Abacavir, Amprenavir, Boceprevir, Citalopram, Darunavir, Delavirdine, Diazepam, Efavirenz, Erythromycin, Fluconazole, Fluvoxamine, Interferon Alfa, Itraconazole, Ketoconazole, Linezolid, Lofexidine, Lopinavir, Nelfinavir, Nilotinib, Paroxetine Hydrochloride, PEG-Interferon, Quetiapine, Ribociclib, Rifapentine, Rilpivirine, Safinamide, Selegiline, St John's Wort, Tipranavir, Vandetanib, Voriconazole, Zidovudine, Zuclopenthixol
PREGNANCY CATEGORY: C
Methadone is not licensed for use in children though it can be employed for the management of neonatal opiate withdrawal syndrome
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SKIN.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
LOCAL.
NEUROMUSCULAR/SKELETAL.
OTIC.
RENAL.
RESPIRATORY.
OTHER.
Page last updated 08/01/2022
Symbol key
Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
