Combivir is zidovudine and lamivudine; Trizivir is zidovudine, abacavir and lamivudine.
- TRADE NAMES: Combivir (ViiV); Novo-AZT; Retrovir (ViiV); Trizivir (ViiV)
- INDICATIONS: HIV infection
- SYNONYM: azidothymidine; AZT
- CLASS: Antiretroviral, Nucleoside analog reverse transcriptase inhibitor
- HALF-LIFE: 0.5–3 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Atovaquone, Bone marrow suppressives, Clarithromycin, Darunavir, Diclofenac, Doxorubicin, Fluconazole, Ganciclovir, Indinavir, Interferon Alfa, Interferon Beta, Lopinavir, Meloxicam, Methadone, NSAIDs, PEG-Interferon, Phenytoin, Probenecid, Pyrimethamine, Ribavirin, Rifampin, Rifapentine, Stavudine, Tipranavir, Valproic Acid
- See adverse reactions attributed to class:
HEMATOLOGICAL TOXICITY, MYOPATHY, LACTIC ACIDOSIS AND SEVERE HEPATOMEGALY, and EXACERBATIONS OF HEPATITIS B
See full prescribing information for complete boxed warning.
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Page last updated 08/07/2024
