Darunavir drug interactions | Litt's Drug Eruption and Reaction Database

Darunavir comment watch save

TRADE NAMES: Prezcobix (Janssen); Prezista (Janssen)
INDICATIONS: HIV infection (must be co-administered with ritonavir and with other antiretroviral agents)
CLASS: Antiretroviral, Covid-19 putative drug, HIV-1 protease inhibitor
HALF-LIFE: 15 hours

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Abacavir, Alfuzosin, Almotriptan, Alosetron, Alprazolam, Amiodarone, Antifungals, Apixaban, Artemether/Lumefantrine, Astemizole, Atorvastatin, Bortezomib, Brinzolamide, Calcium channel blockers, Captopril, Carbamazepine, Ciclesonide, Cisapride, Clarithromycin, Colchicine, Conivaptan, Cyclosporine, CYP2D6 substrates, CYP3A4 inhibitors, inducers and substrates, Dabigatran, Dasatinib, Deferasirox, Delavirdine, Didanosine, Dienogest, Digoxin, Dihydroergotamine, Dronedarone, Duloxetine, Dutasteride, Efavirenz, Elbasvir & Grazoprevir, Enfuvirtide, Eplerenone, Ergotamine, Estrogens, Etravirine, Everolimus, Fentanyl, Fesoterodine, Food, Fusidic Acid, Glecaprevir & Pibrentasvir, Guanfacine, Halofantrine, HMG-CoA reductase inhibitors, Indinavir, Inhaled corticosteroids, Ixabepilone, Ketoconazole, Lidocaine, Lopinavir, Lovastatin, Maraviroc, Meperidine, Methadone, Methylprednisolone, Midazolam, Mifepristone, Mometasone, Nefazodone, Nilotinib, Nisoldipine, Olaparib, P-glycoprotein substrates, Paricalcitol, Paroxetine Hydrochloride, Pazopanib, Phenobarbital, Phenytoin, Pimecrolimus, Pimozide, Prasugrel, Pravastatin, Protease inhibitors, Quetiapine, Quinidine, Quinine, Ranolazine, Rifabutin, Rifampin, Rilpivirine, Rivaroxaban, Romidepsin, Rosuvastatin, Salmeterol, Saquinavir, Saxagliptin, Sertraline, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Sorafenib, St John's Wort, Tacrolimus, Tadalafil, Tamsulosin, Telaprevir, Temsirolimus, Tenofovir Disoproxil, Terfenadine, Theophylline, Tolvaptan, Topotecan, Trazodone, Triazolam, Tricyclic antidepressants, Vardenafil, Viloxazine, Voriconazole, Warfarin, Zidovudine

See adverse reactions attributed to class:
Antiretroviral
Covid-19 putative drug
HIV-1 protease inhibitor

Investigated for treating COVID-19.

Darunavir is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.

Prezcobix is darunavir and cobicistat.

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Page last updated 07/31/2023

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Incidence

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Seriousness

Hospitalization possible
Life threatening
Fatal

Warnings in other populations

Breast feeding

Geriatric

Pediatric