Ketoconazole

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Abemaciclib, Abiraterone, Afatinib, Alcohol, Alfuzosin, Aliskiren, Alitretinoin, Almotriptan, Alprazolam, Amphotericin B, Amprenavir, Anisindione, Anticoagulants, Aprepitant, Aripiprazole, Astemizole, Atazanavir, Avanafil, Axitinib, Beclomethasone, Bedaquiline, Benzodiazepines, Betrixaban, Boceprevir, Bosentan, Bosutinib, Brentuximab Vedotin, Brigatinib, Budesonide, Buprenorphine, Cabazitaxel, Cabozantinib, Caffeine, Calcifediol, Ceritinib, Chlordiazepoxide, Ciclesonide, Cilostazol, Cimetidine, Cinacalcet, Cisapride, Clopidogrel, Clorazepate, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Alafenamide, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Colchicine, Conivaptan, Copanlisib, Crizotinib, Cyclosporine, Cyproterone, Dabigatran, Darifenacin, Darunavir, Dasatinib, Desvenlafaxine, Dexlansoprazole, Dicumarol, Didanosine, Disopyramide, Docetaxel, Dofetilide, Domperidone, Doxercalciferol, Dronedarone, Dutasteride, Echinacea, Elbasvir & Grazoprevir, Eletriptan, Eplerenone, Erlotinib, Erythromycin, Estradiol, Eszopiclone, Everolimus, Fentanyl, Fesoterodine, Fingolimod, Flibanserin, Flunisolide, Fluticasone Propionate, Fosamprenavir, Gastric alkanizers, Halofantrine, HMG-CoA reductase inhibitors, Ibrutinib, Iloperidone, Imatinib, Indacaterol, Indinavir, Irinotecan, Isavuconazonium Sulfate, Ivabradine, Ivacaftor, Ixabepilone, Lanthanum, Lapatinib, Levomilnacipran, Lomitapide, Lopinavir, Lurasidone, Macitentan, Maraviroc, Mefloquine, Methadone, Methylergonovine, Methylprednisolone, Midazolam, Midostaurin, Mizolastine, Mometasone, Naldemedine, Neratinib, Nevirapine, Nilotinib, Nisoldipine, Non-sedating antihistamines, Olaparib, Omeprazole, Ospemifene, Oxybutynin, Paclitaxel, Palbociclib, Pantoprazole, Paricalcitol, Pazopanib, Pimavanserin, Pimecrolimus, Pimozide, Pomalidomide, Ponatinib, Prednisolone, Prednisone, Proton-pump inhibitors, Quetiapine, Quinidine, Rabeprazole, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Ribociclib, Rifampin, Rilpivirine, Rimonabant, Ritonavir, Rivaroxaban, Roflumilast, Romidepsin, Ropivacaine, Rupatadine, Ruxolitinib, Saquinavir, Saxagliptin, Sildenafil, Silodosin, Simeprevir, Simvastatin, Solifenacin, Sonidegib, Sucralfate, Sunitinib, Tacrolimus, Tadalafil, Tamsulosin, Tasimelteon, Telaprevir, Telithromycin, Temsirolimus, Tezacaftor/Ivacaftor, Ticagrelor, Tiotropium, Tofacitinib, Tolterodine, Tolvaptan, Trabectedin, Tramadol, Triamcinolone, Triazolam, Trospium, Ulipristal, Valbenazine, Vardenafil, Vemurafenib, Venetoclax, Venlafaxine, Vilazodone, Vinblastine, Vincristine, Vorapaxar, Warfarin, Zaleplon, Ziprasidone, Zolpidem, Zotarolimus

PREGNANCY CATEGORY: C

HEPATOTOXICITY, QT PROLONGATION AND DRUG INTERACTIONS LEADING TO QT PROLONGATION

See full prescribing information for complete boxed warning.

Our database has 63 adverse reactions for this drug across the following areas

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SKIN
HAIR
NAILS
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
ENDOCRINE/METABOLIC
GASTROINTESTINAL/HEPATIC
HEMATOLOGIC
NEUROMUSCULAR/SKELETAL
OTHER


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Click on the DRUG REVIEW ARTICLE tab (above) to see a review of oral formulations of ketoconazole in the Taylor & Francis journal Expert Opinion on Drug Safety. (Note that non-subscribers to the journal will only be able to see an abstract of the article.)

Page last updated 09/24/2019

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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