Aliskiren

BreastfeedingPediatric
  • TRADE NAMES: Rasilez (Novartis); Tekamlo (Novartis); Tekturna (Novartis); Tekturna HCT (Novartis); Valturna (Novartis)
  • INDICATIONS: Hypertension
  • CLASS: Antihypertensive, Renin inhibitor
  • HALF-LIFE: 24 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

ACE inhibitors, Aldosterone antagonists, Atorvastatin, Candesartan, Celecoxib, Cyclosporine, Diclofenac, Furosemide, Heparin, Irbesartan, Itraconazole, Ketoconazole, Losartan, Meloxicam, Moexipril, NSAIDs, Olmesartan, Potassium salts, Potassium-sparing diuretics, Sacubitril/Valsartan, Tinzaparin, Trandolapril, Verapamil

PREGNANCY CATEGORY: D
category C in first trimester; category D in second and third trimesters

Tekamlo is aliskiren and amlodipine; Tekturna HCT is aliskiren and hydrochlorothiazide; Valturna is aliskiren and valsartan.

Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.

Contra-indicated for concomitant use with angiotensin receptor blockers or angiotensin-converting enzyme (ACE) inhibitors in patients with diabetes.

FETAL TOXICITY

See full prescribing information for complete boxed warning.

Our database has 26 adverse reactions for this drug across the following areas

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SKIN
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
ENDOCRINE/METABOLIC
GASTROINTESTINAL/HEPATIC
NEUROMUSCULAR/SKELETAL
RENAL
RESPIRATORY
OTHER


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Click on the DRUG REVIEW ARTICLE tab (above) to see a review of aliskiren in the Taylor & Francis journal Expert Opinion on Drug Safety. (Note that non-subscribers to the journal will only be able to see an abstract of the article.)

Page last updated 09/19/2018

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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