Losartan
- TRADE NAMES: Cozaar (Merck); Hyzaar (Merck)
- INDICATIONS: Hypertension
- CLASS: Angiotensin receptor antagonist (blocker), Antihypertensive, Covid-19 putative drug
- HALF-LIFE: 2 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Aliskiren, Rifampin, Voriconazole
PREGNANCY CATEGORY: D
category C in first trimester; category D in second and third trimesters
Investigated for treating COVID-19.
Hyzaar is losartan and hydrochlorothiazide.
Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.
CONTRA-INDICATED IN PREGNANCY
See full prescribing information for complete boxed warning.
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SKIN.
HAIR.
NAILS.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
NEUROMUSCULAR/SKELETAL.
RENAL.
RESPIRATORY.
OTHER.
Page last updated 11/18/2023
Symbol key
Incidence
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric