Avalide is irbesartan and hydrochlorothiazide.
Hydrochlorothiazide is a sulfonamide which can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome
- TRADE NAMES: Aprovel (Bristol-Myers Squibb); Avalide (Bristol-Myers Squibb); Avapro (Sanofi-Aventis)
- INDICATIONS: Hypertension, diabetic nephropathy
- CLASS: Angiotensin receptor antagonist (blocker), Antihypertensive
- HALF-LIFE: 11–15 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
ACE inhibitors, Adrenergic neurone blockers, Alcohol, Aldesleukin, Aldosterone antagonists, Aliskiren, Alpha blockers, Alprostadil, Amifostine, Antihypertensives, Antipsychotics, Anxiolytics and hypnotics, Baclofen, Beta blockers, Calcium channel blockers, Carvedilol, Clonidine, Corticosteroids, Cyclosporine, CYP2C8 and CYP2C9 substrates, Diazoxide, Diuretics, Eplerenone, Fluconazole, General anesthetics, Heparins, Hypotensives, Levodopa, Lithium, MAO inhibitors, Methyldopa, Methylphenidate, Moxisylyte, Moxonidine, Nitrates, NSAIDs, Pentoxifylline, Phosphodiesterase 5 inhibitors, Potassium salts, Prostacyclin analogues, Rifamycin derivatives, Rituximab, Tacrolimus, Tizanidine, Tolvaptan, Trimethoprim - PREGNANCY: category C in first trimester; category D in second and third trimesters
- See adverse reactions attributed to class:
FETAL TOXICITY
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Page last updated 03/13/2024
