Tolvaptan
- TRADE NAME: Samsca (Otsuka)
- INDICATIONS: Chronic heart failure, hyponatremia, polycystic kidneys
- CLASS: Vasopressin receptor antagonist
- HALF-LIFE: 6–8 hours
Aprepitant, Barbiturates, Benazepril, Captopril, Carbamazepine, Clarithromycin, Conivaptan, Cyclosporine, Darunavir, Delavirdine, Digoxin, Efavirenz, Enalapril, Fosinopril, Grapefruit Juice, Indinavir, Irbesartan, Itraconazole, Ketoconazole, Lapatinib, Lisinopril, Lovastatin, Miconazole, Nefazodone, Nelfinavir, Olmesartan, Oxcarbazepine, P-gp inhibitors, Phenytoin, Quinapril, Ramipril, Rifabutin, Rifampin, Rifapentin, Rifapentine, Ritonavir, Saquinavir, St John's Wort, Strong CYP3A inhibitors, Telithromycin, Voriconazole
PREGNANCY CATEGORY: C
March 2013. The U.S. Food and Drug Administration (FDA) has determined that tolvaptan should not be used for longer than 30 days and should not be used in patients with underlying liver disease because it can cause liver injury, potentially requiring liver transplant or death.
See full prescribing information for complete boxed warning.
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Page last updated 10/06/2023
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Incidence
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric