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- TRADE NAMES: Atripla (Gilead); Sustiva (Bristol-Myers Squibb)
- INDICATIONS: HIV infection
- CLASS: Antiretroviral, CYP1A2 inhibitor, CYP3A4 inducer, Non-nucleoside reverse transcriptase inhibitor
- HALF-LIFE: 52–76 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Alprazolam, Amprenavir, Aripiprazole, Artesunate, Atazanavir, Atorvastatin, Atovaquone, Avapritinib, Benzodiazepines, Bepridil, Boceprevir, Bortezomib, Brentuximab Vedotin, Budesonide, Buprenorphine, Bupropion, Carbamazepine, Carvedilol, Caspofungin, Chlordiazepoxide, Cisapride, Citalopram, Clarithromycin, Clonazepam, Clopidogrel, Clorazepate, CNS depressants, Cobimetinib, Colchicine, Conivaptan, Crizotinib, Cyclosporine, CYP2B6 inhibitors and inducers, CYP2C19 substrates, CYP2C9 substrates, CYP3A4 substrates and inducers, Darunavir, Dasatinib, Deferasirox, Deflazacort, Diazepam, Dihydroergotamine, Diltiazem, Doravirine, Dronedarone, Elbasvir & Grazoprevir, Enzalutamide, Eplerenone, Ergot, Etravirine, Everolimus, Exemestane, Fentanyl, Finerenone, Flurazepam, Fosamprenavir, Fosphenytoin, Gefitinib, Glecaprevir & Pibrentasvir, Grapefruit Juice, Guanfacine, Halofantrine, Hydroxyzine, Ibrexafungerp, Imatinib, Indinavir, Itraconazole, Ixabepilone, Lapatinib, Lemborexant, Levomepromazine, Levonorgestrel, Linagliptin, Lopinavir, Lorazepam, Lovastatin, Lumateperone, Lurasidone, Maraviroc, Methadone, Methysergide, Midazolam, Mifepristone, Neratinib, Nevirapine, Nifedipine, Nilotinib, Nisoldipine, Olaparib, Ombitasvir/Paritaprevir/Ritonavir, Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir, Oral Contraceptives, Oxazepam, Paclitaxel, Palbociclib, Pazopanib, Phenytoin, Pimecrolimus, Pimozide, Posaconazole, Pravastatin, Praziquantel, Progestogens, Propafenone, Protease inhibitors, Quazepam, Raltegravir, Ranolazine, Rifabutin, Rifampin, Rilpivirine, Ritonavir, Rivaroxaban, Roflumilast, Romidepsin, Salmeterol, Saquinavir, Saxagliptin, Sertraline, Simeprevir, Simvastatin, Sirolimus, Sofosbuvir & Velpatasvir, Sofosbuvir/Velpatasvir/Voxilaprevir, Sonidegib, Sorafenib, SSRIs, St John's Wort, Sunitinib, Tacrolimus, Tadalafil, Telaprevir, Temazepam, Ticagrelor, Tipranavir, Tocilizumab, Tolvaptan, Toremifene, Triazolam, Ulipristal, Vandetanib, Vemurafenib, Venetoclax, Vilazodone, Vitamin K antagonists, Voriconazole, Warfarin, Zuclopenthixol
- See adverse reactions attributed to class:
Atripla is efavirenz, emtricitabine and tenofovir disoproxil.
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Click on this DRUG REVIEW ARTICLE tab (above) to see a review of efavirenz in the Informa Healthcare journal Expert Opinion on Drug Safety
(Note that non-subscribers to the journal will only be able to see an abstract of the article.)
Page last updated 07/31/2023
