Levomepromazine
- TRADE NAME: Nozinan (Sanofi-Aventis)
- INDICATIONS: Pain, anxiety and distress in people with terminal illness, psychosis, schizophrenia
- SYNONYM: methotrimeprazine
- CLASS: Antipsychotic, Neuroleptic, Phenothiazine
- HALF-LIFE: ~20 hours
ACE inhibitors, Adrenergic neurone blockers, Alcohol, Alpha blockers, Amantadine, Amiodarone, Angiotensin II receptor antagonists, Antacids, Antiarrhythmics prolonging QT interval, Antimuscarinics, Antiolytics and hypnotics, Apomorphine, Arsenic, Artemether/Lumefantrine, Atomoxetine, Barbiturates, Beta blockers, Bromocriptine, Cabergoline, Caffeine, Calcium channel blockers, Carbamazepine, Cimetidine, Clonidine, Cyclobenzaprine, Diazoxide, Disopyramide, Diuretics, Dronedarone, Droperidol, Duloxetine, Efavirenz, Ephedrine, Eszopiclone, Ethosuximide, General anesthetics, Histamine, Hydralazine, Kaolin, Levodopa, Lithium, Lurasidone, Memantine, Metaxalone, Methyldopa, Metoclopramide, Milnacipran, Minoxidil, Moxifloxacin, Moxonidine, Myelosuppressives, Nitrates, Nitroprusside, Opioid analgesics, Oxcarbazepine, Paliperidone, Pentamidine, Pergolide, Phenytoin, Pimozide, Pramipexole, Primidone, Ramelteon, Ritonavir, Ropinirole, Rotigotine, Saquinavir, Sodium Oxybate, Sodium Phenylbutyrate, Sotalol, Succinylcholine, Sulfonylureas, Sympathomimetics, Tetrabenazine, Tiagabine, Tramadol, Tricyclic antidepressants, Valproic Acid
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Nozinan is not indicated for the treatment of patients with dementia-related psychosis.
Contraindicated in cases of coma or CNS depression due to alcohol, hypnotics, analgesics or narcotics; also in patients with blood dyscrasia, hepatic problems or a sensitivity to phenothiazines.
Not available in the USA.
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Page last updated 07/31/2023
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
