APL DIFFERENTIATION SYNDROME and ECG ABNORMALITIES
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- TRADE NAMES: Fowler's Solution; Trisenox (Cephalon)
- INDICATIONS: Acute promyelocytic leukemia, psoriasis (in the early 1900s), devitalization of pulp in dental procedures
- SYNONYM: Arsenic trioxide (Trisenox); Potassium arsenite solution (Fowler's solution)
- CLASS: Antineoplastic / anticancer agent (see also Immune checkpoint inhibitor), Trace element
- HALF-LIFE: 10–14 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Abacavir, Acetazolamide, Alfuzosin, Aloe Vera (Gel, Juice, Leaf), Amiodarone, Amitriptyline, Amphotericin B, Artemether/Lumefantrine, Bretylium, Chloroquine, Chlorpromazine, Ciprofloxacin, Clomipramine, Clozapine, Disopyramide, Diuretics, Dronedarone, Droperidol, Enoxacin, Erythromycin, Fluphenazine, Gadobutrol, Garlic, Gatifloxacin, Ginger, Ginseng, Haloperidol, Indacaterol, Levofloxacin, Levomepromazine, Lithium, Lomefloxacin, Mesoridazine, Moxifloxacin, Nilotinib, Norfloxacin, Ofloxacin, Phenothiazines, Pimozide, Procainamide, Prochlorperazine, Promethazine, QT prolonging antipsychotics, Quetiapine, Quinidine, Quinine, Quinolones, Sotalol, Sparfloxacin, Tetrabenazine, Thioridazine, Toremifene, Trifluoperazine, Vandetanib, Vemurafenib, Ziprasidone, Zuclopenthixol
- See adverse reactions attributed to class:
Antineoplastic / anticancer agent (see also Immune checkpoint inhibitor)
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Page last updated 09/05/2025
