Artemether/Lumefantrine tablets should not be used to treat severe malaria or to prevent malaria.
- Trade Name: Coartem (Novartis)
- Indications: Acute, uncomplicated malaria infections due to Plasmodium falciparum in patients of 5kg bodyweight and above
- Class: Antimalarial
- Half-life: ~2 hours (artemether); 3–6 days (lumefantrine)
- Clinically important, potentially hazardous interactions with:
Amiodarone, Amitriptyline, Amoxapine, Antimalarials, Antiretrovirals, Arsenic, Astemizole, Atazanavir, Atovaquone/Proguanil, Azithromycin, Carbamazepine, Ciprofloxacin, Citalopram, Clomipramine, Conivaptan, CYP2D6 substrates, CYP3A4 inducers, inhibitors or substrates, Darunavir, Dasatinib, Degarelix, Delavirdine, Disopyramide, Dolasetron, Duloxetine, Flecainide, Halofantrine, Hormonal contraceptives, Imipramine, Indinavir, Itraconazole, Lapatinib, Levofloxacin, Levomepromazine, Lopinavir, Mefloquine, Moxifloxacin, Nelfinavir, Norfloxacin, Ofloxacin, Paroxetine Hydrochloride, Pazopanib, Phenytoin, Pimozide, Procainamide, Quinidine, Quinine, Rifampin, Risperidone, Sotalol, St John's Wort, Telavancin, Telithromycin, Terfenadine, Tipranavir, Venlafaxine, Voriconazole, Vorinostat, Ziprasidone, Zuclopenthixol
- See adverse reactions attributed to class:
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Page last updated 08/20/2025
