Paroxetine Hydrochloride
- TRADE NAMES: Paxil (GSK); Paxil CR (GSK); Seroxat (GSK)
- INDICATIONS: Depression, obsessive-compulsive disorder, panic disorder, social and generalized anxiety disorders, post-traumatic stress disorder
- CLASS: Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
- HALF-LIFE: 21 hours
Alcohol, Amitriptyline, Amphetamines, Antiepileptics, Aprepitant, Aripiprazole, Artemether/Lumefantrine, Asenapine, Aspirin, Astemizole, Atomoxetine, Barbiturates, Clarithromycin, Clozapine, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Alafenamide, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Coumarins, Cyproheptadine, Darifenacin, Darunavir, Deutetrabenazine, Dexibuprofen, Dextroamphetamine, Diethylpropion, Digitalis, Digoxin, Duloxetine, Eluxadoline, Entacapone, Erythromycin, Galantamine, Iloperidone, Isocarboxazid, Linezolid, Lithium, MAO inhibitors, Mazindol, Methadone, Methamphetamine, Methylene blue, Methylphenidate, Metoprolol, Moclobemide, Molindone, NSAIDs, Oliceridine, Perphenazine, Phendimetrazine, Phenelzine, Phenobarbital, Phentermine, Phenylpropanolamine, Phenytoin, Pimozide, Primidone, Procyclidine, Propafenone, Propranolol, Pseudoephedrine, Ranolazine, Rasagiline, Risperidone, Ritonavir, Selegiline, Sibutramine, St John's Wort, Sumatriptan, Sympathomimetics, Tamoxifen, Tamsulosin, Tetrabenazine, Thioridazine, Tramadol, Tranylcypromine, Trazodone, Tricyclic antidepressants, Troleandomycin, Tryptophan, Valbenazine, Vortioxetine
PREGNANCY CATEGORY: D
For menopausal indications see separate entry for paroxetine mesylate.
See full prescribing information for complete boxed warning.
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Page last updated 07/31/2023
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
