See also separate profiles for emtricitabine and tenofovir disoproxil.
- TRADE NAME: Stribild (Gilead)
- INDICATIONS: HIV-1 infection
- CLASS: Antiretroviral, CYP3A inhibitor (cobicistat), Integrase strand transfer inhibitor (elvitegravir), Nucleoside analog reverse transcriptase inhibitor (emtricitabine and tenofovir disoproxil)
- HALF-LIFE: 3.5 hours (cobicistat); 13 hours (elvitegravir); 10 hours (emtricitabine); 12–18 hours (tenofovir disoproxil)
- FDA APPROVAL DATE: 08/27/2012
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Acyclovir, Adefovir, Amiodarone, Amitriptyline, Amlodipine, Antacids, Antirarrhythmics, Antiretrovirals, Atorvastatin, Benzodiazepines, Bepridil, Beta blockers, Bosentan, Buprenorphine, Bupropion, Buspirone, Calcium channel blockers, Carbamazepine, Cidofovir, Clarithromycin, Clonazepam, Clorazepate, Colchicine, Cyclosporine, Desipramine, Dexamethasone, Diazepam, Digoxin, Diltiazem, Disopyramide, Drugs affecting renal function, Elbasvir & Grazoprevir, Emtricitabine, Estazolam, Ethosuximide, Felodipine, Flecainide, Flurazepam, Fluticasone Propionate, Ganciclovir, Hormonal contraceptives, Imipramine, Immunosuppressants, Itraconazole, Ketoconazole, Lamivudine, Ledipasvir & Sofosbuvir, Lidocaine, Metoprolol, Mexiletine, Midazolam, Naloxone, Neuroleptics, Nicardipine, Nifedipine, Non-nucleoside reverse transcriptase inhibitors, Nortriptyline, Oxcarbazepine, Paroxetine Hydrochloride, Perphenazine, Phenobarbital, Phenytoin, Propafenone, Protease inhibitors, Quinidine, Rifabutin, Rifapentine, Risperidone, Ritonavir, Salmeterol, Sedatives / hypnotics, Sildenafil, Simeprevir, Sirolimus, SSRIs, Tacrolimus, Tadalafil, Telithromycin, Tenofovir Disoproxil, Thioridazine, Timolol, Trazodone, Tricyclic antidepressants, Valacyclovir, Valganciclovir, Vardenafil, Verapamil, Voriconazole, Warfarin, Zolpidem
- See adverse reactions attributed to class:
LACTIC ACIDOSIS/SEVERE HEPATOMEGALY WITH STEATOSIS and POST TREATMENT ACUTE EXACERBATION OF HEPATITIS B
See full prescribing information for complete boxed warning.
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Page last updated 07/31/2023
