Colchicine drug interactions | Litt's Drug Eruption and Reaction Database

Colchicine comment watch save

TRADE NAMES: ColBenemid; Colchiquim; Colcrys; Colgout; Goutnil; Kolkicin; Konicine
INDICATIONS: Gouty arthritis (in adults), gout, familial Mediterranean fever
CLASS: Alkaloid, Anti-inflammatory, Covid-19 putative drug
HALF-LIFE: 27–31 hours (following multiple doses)

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Amiodarone, Aprepitant, Atazanavir, Atorvastatin, Azithromycin, Boceprevir, Clarithromycin, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Alafenamide, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Conivaptan, Cyanocobalamin, Cyclosporine, Darunavir, Dasatinib, Delavirdine, Digoxin, Diltiazem, Efavirenz, Erythromycin, Fenofibrate, Fibrates, Fluvastatin, Gemfibrozil, Grapefruit Juice, HMG-CoA reductase inhibitors, Indinavir, Itraconazole, Ketoconazole, Lapatinib, Lopinavir, Ombitasvir/Paritaprevir/Ritonavir, P-glycoprotein inhibitors or inducers, Pravastatin, Protease inhibitors, Ritonavir, Rosuvastatin, Saxagliptin, Simvastatin, Strong CYP3A4 inhibitors, Telithromycin, Troleandomycin, Verapamil, Voriconazole

See adverse reactions attributed to class:
Anti-inflammatory
Covid-19 putative drug

Investigated for treating COVID-19.

Contra-indicated in patients with renal or hepatic impairment where P-glycoprotein or strong CYP3A4 inhibitors are also prescribed.

Low-dose colchicine (0.5 mg daily) has been approved by the FDA for secondary prevention in patients with coronary disease.

Please login to view the rest of this drug profile.

Page last updated 05/17/2025

Search drug eruptions and reactions data anytime, anywhere

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Hospitalization possible
Life threatening
Fatal

Breast feeding

Geriatric

Pediatric