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- TRADE NAME: Sprycel (Bristol-Myers Squibb)
- INDICATIONS: Leukemia (chronic myeloid); acute lymphoblastic leukemia
- CLASS: Antineoplastic / anticancer agent (see also Immune checkpoint inhibitor), Bcr-Abl tyrosine kinase inhibitor / (Breakpoint cluster region Abelson (Bcr-Abl) tyrosine kinase inhibitor, Tyrosine kinase inhibitor, Vascular endothelial growth factor (VEGF) inhibitor / antagonist
- HALF-LIFE: 3–5 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Abciximab, Alfentanil, Alfuzosin, Ambrisentan, Antacids, Anticoagulants, Antiplatelet agents, Aprepitant, Argatroban, Artemether/Lumefantrine, Astemizole, Atazanavir, Atorvastatin, Boceprevir, Cabazitaxel, Carbamazepine, Chloroquine, Ciclesonide, Cilostazol, Cinacalcet, Ciprofloxacin, Cisapride, Clarithromycin, Clopidogrel, Clozapine, Colchicine, Conivaptan, Cyclosporine, CYP3A4 inhibitors, inducers and substrates, Dabigatran, Darunavir, Deferasirox, Dexamethasone, Dihydroergotamine, Docetaxel, Dronedarone, Efavirenz, Eptifibatide, Ergotamine, Erythromycin, Eszopiclone, Famotidine, Fentanyl, Fesoterodine, Gadobutrol, Gefitinib, H2 antagonists, Indinavir, Itraconazole, Ixabepilone, Ketoconazole, Lopinavir, Lurasidone, Maraviroc, Meloxicam, Nefazodone, Nelfinavir, Nilotinib, Omeprazole, Pantoprazole, Phenobarbital, Phenytoin, Pimozide, Proton pump inhibitors, QT prolonging agents, Quinidine, Quinine, Rifampin, Ritonavir, Saquinavir, Saxagliptin, Sildenafil, Simvastatin, Sirolimus, St John's Wort, Tacrolimus, Tadalafil, Temsirolimus, Terfenadine, Tetrabenazine, Thioridazine, Tiagabine, Tinzaparin, Vardenafil, Ziprasidone
- See adverse reactions attributed to class:
Antineoplastic / anticancer agent (see also Immune checkpoint inhibitor)
Vascular endothelial growth factor (VEGF) inhibitor / antagonist
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Page last updated 04/06/2025
