CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH: ACE inhibitors, Adrenergic neurone blockers, Alcohol, Aliskiren , Alpha blockers, Angiotensin II receptor antagonists, Anticoagulants, Antidepressants, Antiplatelet agents, Aspirin , Baclofen , Beta blockers, Bile acid sequestrants, Calcium channel blockers, Cardiac glycosides, Cholestyramine , Clonidine , Clopidogrel , Collagenase, Conivaptan , Corticosteroids, Coumarins, Cyclosporine , Dabigatran , Dasatinib , Desmopressin , Diazoxide , Digoxin , Diuretics, Drotrecogin Alfa , Eplerenone , Erlotinib , Glucosamine , Haloperidol , Heparins, Hydralazine , Ibritumomab , Iloprost , Ketorolac , Lithium , Methotrexate , Methyldopa , Mifamurtide, Minoxidil , Moxonidine , Nitrates, Nitroprusside , NSAIDs, Pemetrexed , Penicillamine , Pentosan , Pentoxifylline , Phenindione, Pralatrexate , Prasugrel , Probenecid , Prostacyclin analogues, Quinolones, Ritonavir , Serotonin/norepinephrine reuptake inhibitors, SSRIs, Sulfonylureas, Tacrolimus , Thrombolytic agents, Tositumomab & Iodine131 , Treprostinil , Vancomycin , Venlafaxine , Vitamin K antagonists, Voriconazole , Zidovudine PREGNANCY: category D from 30 weeks gestation
Notes
NSAIDs may cause an increased risk of serious cardiovascular and gastrointestinal adverse events, which can be fatal. This risk may increase with duration of use.
Black Box Warning
CARDIOVASCULAR AND GASTROINTESTINAL RISKS
See full prescribing information for complete boxed warning.
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Page last updated 02/04/2025