Methotrexate
- TRADE NAMES: Lantarel; Ledertrexate; Maxtrex; Metex; Otrexup; Rasuvo (Medac); Rheumatrex (Stada); Texate
- INDICATIONS: Carcinomas, leukemias, lymphomas, psoriasis, rheumatoid arthritis
- SYNONYM: amethopterin; MTX
- CLASS: Antimetabolite, Antipsoriatic agent, Disease-modifying antirheumatic drug (DMARD), Folic acid antagonist
- HALF-LIFE: 3–10 hours
Acemetacin, Acitretin, Aldesleukin, Aminoglycosides, Amiodarone, Amoxicillin, Ampicillin, Aspirin, Bacampicillin, Bismuth, Carbenicillin, Chloroquine, Ciprofloxacin, Cisplatin, Cloxacillin, Co-Trimoxazole, Cyclopenthiazide, Dapsone, Demeclocycline, Dexamethasone, Diclofenac, Dicloxacillin, Doxycycline, Echinacea, Etodolac, Etoricoxib, Etretinate, Fenoprofen, Flurbiprofen, Folic acid antagonists, Gadobenate, Haloperidol, Hydrocortisone, Ibuprofen, Indomethacin, Infliximab, Ketoprofen, Ketorolac, Leflunomide, Magnesium trisalicylate, Meclofenamate, Mefenamic Acid, Meloxicam, Methicillin, Mezlocillin, Minocycline, Nabumetone, Nafcillin, Naproxen, Natalizumab, NSAIDs, Omeprazole, Oxacillin, Oxaprozin, Oxtriphylline, Oxytetracycline, Pantoprazole, Paromomycin, Penicillin G, Penicillin V, Penicillins, Phenylbutazone, Piperacillin, Piperacillin/Tazobactam, Piroxicam, Polypeptide antibiotics, Prednisolone, Prednisone, Pristinamycin, Probenecid, Procarbazine, Rofecoxib, Salicylates, Salsalate, Sapropterin, Sulfadiazine, Sulfamethoxazole, Sulfapyridine, Sulfasalazine, Sulfisoxazole, Sulindac, Tafamidis meglumine, Taxobactam, Tenoxicam, Tetracycline, Ticarcillin, Tolmetin, Trimethoprim, Vaccines
PREGNANCY CATEGORY: X
August 2023: UK Medicines and Healthcare products Regulatory Agency
Methotrexate: advise patients to take precautions in the sun to avoid photosensitivity reactions
Photosensitivity reactions are known side effects of methotrexate treatment and can be
severe. Patients should be advised to take precautions to protect their skin in the sun.
See full prescribing information for complete boxed warning.
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Click on the DRUG REVIEW ARTICLE tab (above) to see a review of methotrexate in the Taylor & Francis journal Expert Opinion on Drug Safety. (Note that non-subscribers to the journal will only be able to see an abstract of the article.)
Page last updated 02/21/2024
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Incidence
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric