Co-trimoxazole is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.
Co-trimoxazole is sulfamethoxazole and trimethoprim.
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- TRADE NAMES: Anitrim; Apo-Sulfatrim; Bactelan; Bactrim (GSK); Batrizol; Cotrim; Ectaprim; Esteprim; Isobac; Pro-Trin; Roubac; Septra (Monarch); Sulfatrim; Trimzol; Trisulfa
- INDICATIONS: Various infections caused by susceptible organismsSee individual drugs of this combination for adverse effects: Sulfamethoxazole, Trimethoprim
- SYNONYM: Cotrimoxazole; sulfamethoxazole-trimethoprim; SMX-TMP; SMZ-TMP; TMP-SMX; TMP-SMZ
- CLASS: Antibiotic, Antibiotic; sulfonamide, Antimicrobial
- HALF-LIFE: 6–10 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Anticoagulants, Azathioprine, Cyclosporine, Dofetilide, Isotretinoin, Methotrexate, Prilocaine, Repaglinide, Warfarin
- See adverse reactions attributed to class:
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Page last updated 05/20/2025
