Isotretinoin

BreastfeedingPediatric
  • TRADE NAMES: Accutane (Roche); Amnesteem (Genpharm); Claravis (Barr); Clarus; Isotrex; Roaccutan; Roaccutane (Roche); Roacutan; Roacuttan; Sotret
  • INDICATIONS: Cystic acne
  • SYNONYM: 13-cis-retinoic acid
  • CLASS: Retinoid
  • HALF-LIFE: 21–24 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Acitretin, Alcohol (ethyl), Antacids, Bexarotene, Carbamazepine, Cholestyramine, Co-Trimoxazole, Corticosteroids, Dairy products, Minocycline, Oral Contraceptives, Phenytoin, Retinoids, St John's Wort, Tetracycline, Tetracyclines, Vitamin A

PREGNANCY CATEGORY: X

Oral retinoids can cause birth defects, and women should avoid isotretinoin when pregnant or trying to conceive.

Our database has 138 adverse reactions for this drug across the following areas

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SKIN.
HAIR.
NAILS.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
RESPIRATORY.
OTHER.


Page last updated 01/09/2020

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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