Carbamazepine is the main cause of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and the hypersensitivity syndrome in Han Chinese, and in peoples of other Southeast Asian countries, as a result of a strong pharmacogenetic association that has been reported in these patients between the human leukocyte antigen (HLA)-B*1502 and carbamazepine.
- TRADE NAMES: Apo-Carbamazepine; Atreol; Carbatrol; Epitol (Teva); Foxsalepsin; Kodapan; Lexin; Mazepine; Sirtal; Tegretol (Novartis); Tegretol XR; Teril; Timonil
- INDICATIONS: Epilepsy, pain or trigeminal neuralgia
- CLASS: Anticonvulsant (see also antiepileptic (anti-seizure)), Antipsychotic, CYP1A2 inducer, CYP3A4 inducer, Mood stabilizer
- HALF-LIFE: 18–55 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Abiraterone, Acetaminophen, Acetylcysteine, Adenosine, Afatinib, Amitriptyline, Amlodipine, Amprenavir, Apixaban, Apremilast, Aprepitant, Aripiprazole, Artemether/Lumefantrine, Bictegravir/Emtricitabine/Tenofovir Alafenamide, Boceprevir, Brigatinib, Brivaracetam, Buprenorphine, Cabazitaxel, Cabozantinib, Caffeine, Caspofungin, Cefixime, Cenobamate, Ceritinib, Charcoal, Citalopram, Clarithromycin, Clobazam, Clopidogrel, Clorazepate, Clozapine, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Cobimetinib, Copanlisib, Crizotinib, Dabigatran, Daclatasvir, Darunavir, Dasatinib, Deflazacort, Delavirdine, Dexamethasone, Diltiazem, Doravirine, Doravirine/Lamiduvine/Tenofovir Disoproxil, Doxacurium, Doxycycline, Dronedarone, Efavirenz, Elbasvir & Grazoprevir, Eliglustat, Emtricitabine/Rilpivirine/Tenofovir Alafenamide, Enzalutamide, Erlotinib, Erlotinib, Erythromycin, Eslicarbazepine, Estradiol, Ethosuximide, Etravirine, Ezogabine, Felodipine, Fesoterodine, Flibanserin, Fosamprenavir, Fostemsavir, Gefitinib, Glecaprevir & Pibrentasvir, Ibrexafungerp, Ibrutinib, Idelalisib, Imatinib, Indinavir, Influenza Vaccine, Isavuconazonium Sulfate, Isotretinoin, Itraconazole, Ixabepilone, Ixazomib, Lacosamide, Lapatinib, Ledipasvir & Sofosbuvir, Lemborexant, Lesinurad, Levetiracetam, Levomepromazine, Levonorgestrel, Linezolid, Lopinavir, Lumateperone, Methylprednisolone, Midazolam, Midostaurin, Mifepristone, Naldemedine, Nelfinavir, Neratinib, Nevirapine, Nifedipine, Nilotinib, Nintedanib, Olanzapine, Olaparib, Oliceridine, Ombitasvir/Paritaprevir/Ritonavir, Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir, Ondansetron, Osilodrostat, Osimertinib, Oxcarbazepine, Oxtriphylline, Paclitaxel, Palbociclib, Paliperidone, Perampanel, Pimavanserin, Piracetam, Ponatinib, Ponesimod, Prednisolone, Propoxyphene, Regorafenib, Rilpivirine, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Roflumilast, Romidepsin, Rufinamide, Simeprevir, Simvastatin, Sodium Picosulfate, Sofosbuvir, Sofosbuvir & Velpatasvir, Sofosbuvir/Velpatasvir/Voxilaprevir, Solifenacin, Sonidegib, Sorafenib, St John's Wort, Sunitinib, Telaprevir, Telithromycin, Temsirolimus, Tenofovir Alafenamide, Terbinafine, Tezacaftor/Ivacaftor, Thalidomide, Tiagabine, Ticagrelor, Tipranavir, Tolvaptan, Tramadol, Triamcinolone, Troleandomycin, Ulipristal, Valbenazine, Vandetanib, Vemurafenib, Venetoclax, Verapamil, Vorapaxar, Voriconazole, Vortioxetine, Ziprasidone, Zuclopenthixol
- See adverse reactions attributed to class:
SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE; APLASTIC ANEMIA AND AGRANULOCYTOSIS
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Page last updated 09/07/2024
