Carbamazepine

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Abiraterone, Acetaminophen, Acetylcysteine, Adenosine, Afatinib, Amitriptyline, Amlodipine, Amprenavir, Apixaban, Apremilast, Aprepitant, Aripiprazole, Artemether/Lumefantrine, Bictegravir/Emtricitabine/Tenofovir Alafenamide, Boceprevir, Brigatinib, Brivaracetam, Buprenorphine, Cabazitaxel, Cabozantinib, Caffeine, Caspofungin, Cefixime, Cenobamate, Ceritinib, Charcoal, Citalopram, Clarithromycin, Clobazam, Clopidogrel, Clorazepate, Clozapine, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Cobimetinib, Copanlisib, Crizotinib, Dabigatran, Daclatasvir, Darunavir, Dasatinib, Deflazacort, Delavirdine, Dexamethasone, Diltiazem, Doxacurium, Doxycycline, Dronedarone, Efavirenz, Elbasvir & Grazoprevir, Eliglustat, Emtricitabine/Rilpivirine/Tenofovir Alafenamide, Enzalutamide, Erythromycin, Eslicarbazepine, Estradiol, Ethosuximide, Etravirine, Ezogabine, Felodipine, Fesoterodine, Flibanserin, Fosamprenavir, Gefitinib, Glecaprevir & Pibrentasvir, Ibrutinib, Idelalisib, Imatinib, Indinavir, Influenza Vaccine, Isavuconazonium Sulfate, Isotretinoin, Itraconazole, Ixabepilone, Ixazomib, Lacosamide, Lapatinib, Ledipasvir & Sofosbuvir, Lesinurad, Levetiracetam, Levomepromazine, Levonorgestrel, Linezolid, Lopinavir, Methylprednisolone, Midazolam, Midostaurin, Mifepristone, Naldemedine, Nelfinavir, Neratinib, Nevirapine, Nifedipine, Nilotinib, Nintedanib, Olanzapine, Olaparib, Ombitasvir/Paritaprevir/Ritonavir, Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir, Ondansetron, Osimertinib, Oxcarbazepine, Oxtriphylline, Paclitaxel, Palbociclib, Paliperidone, Perampanel, Pimavanserin, Piracetam, Ponatinib, Prednisolone, Propoxyphene, Regorafenib, Rilpivirine, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Roflumilast, Romidepsin, Rufinamide, Simeprevir, Simvastatin, Sodium Picosulfate, Sofosbuvir, Sofosbuvir & Velpatasvir, Sofosbuvir/Velpatasvir/Voxilaprevir, Solifenacin, Sonidegib, Sorafenib, St John's Wort, Sunitinib, Telaprevir, Telithromycin, Temsirolimus, Tenofovir Alafenamide, Terbinafine, Tezacaftor/Ivacaftor, Thalidomide, Tiagabine, Ticagrelor, Tipranavir, Tolvaptan, Tramadol, Triamcinolone, Troleandomycin, Ulipristal, Valbenazine, Vandetanib, Vemurafenib, Venetoclax, Verapamil, Vorapaxar, Voriconazole, Vortioxetine, Ziprasidone, Zuclopenthixol

PREGNANCY CATEGORY: D

Carbamazepine is the main cause of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and the hypersensitivity syndrome in Han Chinese, and in peoples of other Southeast Asian countries, as a result of a strong pharmacogenetic association that has been reported in these patients between the human leukocyte antigen (HLA)-B*1502 and carbamazepine.

SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE; APLASTIC ANEMIA AND AGRANULOCYTOSIS


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Our database has 160 adverse reactions for this drug across the following areas

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SKIN.
HAIR.
NAILS.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
OTIC.
RENAL.
RESPIRATORY.
OTHER.


Page last updated 11/05/2020

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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