Carbamazepine
- TRADE NAMES: Apo-Carbamazepine; Atreol; Carbatrol; Epitol (Teva); Foxsalepsin; Kodapan; Lexin; Mazepine; Sirtal; Tegretol (Novartis); Tegretol XR; Teril; Timonil
- INDICATIONS: Epilepsy, pain or trigeminal neuralgia
- CLASS: Anticonvulsant, Antipsychotic, CYP1A2 inducer, CYP3A4 inducer, Mood stabilizer
- HALF-LIFE: 18–55 hours
Abiraterone, Acetaminophen, Acetylcysteine, Adenosine, Afatinib, Amitriptyline, Amlodipine, Amprenavir, Apixaban, Apremilast, Aprepitant, Aripiprazole, Artemether/Lumefantrine, Bictegravir/Emtricitabine/Tenofovir Alafenamide, Boceprevir, Brigatinib, Brivaracetam, Buprenorphine, Cabazitaxel, Cabozantinib, Caffeine, Caspofungin, Cefixime, Cenobamate, Ceritinib, Charcoal, Citalopram, Clarithromycin, Clobazam, Clopidogrel, Clorazepate, Clozapine, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Cobimetinib, Copanlisib, Crizotinib, Dabigatran, Daclatasvir, Darunavir, Dasatinib, Deflazacort, Delavirdine, Dexamethasone, Diltiazem, Doravirine, Doravirine/Lamiduvine/Tenofovir Disoproxil, Doxacurium, Doxycycline, Dronedarone, Efavirenz, Elbasvir & Grazoprevir, Eliglustat, Emtricitabine/Rilpivirine/Tenofovir Alafenamide, Enzalutamide, Erlotinib, Erlotinib, Erythromycin, Eslicarbazepine, Estradiol, Ethosuximide, Etravirine, Ezogabine, Felodipine, Fesoterodine, Flibanserin, Fosamprenavir, Fostemsavir, Gefitinib, Glecaprevir & Pibrentasvir, Ibrexafungerp, Ibrutinib, Idelalisib, Imatinib, Indinavir, Influenza Vaccine, Isavuconazonium Sulfate, Isotretinoin, Itraconazole, Ixabepilone, Ixazomib, Lacosamide, Lapatinib, Ledipasvir & Sofosbuvir, Lemborexant, Lesinurad, Levetiracetam, Levomepromazine, Levonorgestrel, Linezolid, Lopinavir, Lumateperone, Methylprednisolone, Midazolam, Midostaurin, Mifepristone, Naldemedine, Nelfinavir, Neratinib, Nevirapine, Nifedipine, Nilotinib, Nintedanib, Olanzapine, Olaparib, Oliceridine, Ombitasvir/Paritaprevir/Ritonavir, Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir, Ondansetron, Osilodrostat, Osimertinib, Oxcarbazepine, Oxtriphylline, Paclitaxel, Palbociclib, Paliperidone, Perampanel, Pimavanserin, Piracetam, Ponatinib, Ponesimod, Prednisolone, Propoxyphene, Regorafenib, Rilpivirine, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Roflumilast, Romidepsin, Rufinamide, Simeprevir, Simvastatin, Sodium Picosulfate, Sofosbuvir, Sofosbuvir & Velpatasvir, Sofosbuvir/Velpatasvir/Voxilaprevir, Solifenacin, Sonidegib, Sorafenib, St John's Wort, Sunitinib, Telaprevir, Telithromycin, Temsirolimus, Tenofovir Alafenamide, Terbinafine, Tezacaftor/Ivacaftor, Thalidomide, Tiagabine, Ticagrelor, Tipranavir, Tolvaptan, Tramadol, Triamcinolone, Troleandomycin, Ulipristal, Valbenazine, Vandetanib, Vemurafenib, Venetoclax, Verapamil, Vorapaxar, Voriconazole, Vortioxetine, Ziprasidone, Zuclopenthixol
PREGNANCY CATEGORY: D
Carbamazepine is the main cause of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and the hypersensitivity syndrome in Han Chinese, and in peoples of other Southeast Asian countries, as a result of a strong pharmacogenetic association that has been reported in these patients between the human leukocyte antigen (HLA)-B*1502 and carbamazepine.
SERIOUS DERMATOLOGIC REACTIONS AND HLA-B*1502 ALLELE; APLASTIC ANEMIA AND AGRANULOCYTOSIS
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Page last updated 08/12/2023
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
