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- TRADE NAMES: Contergan; Distaval; Kevadon; Thalomid (Celgene)
- INDICATIONS: Graft-versus-host reactions, recalcitrant aphthous stomatitis
- CLASS: Covid-19 putative drug, Immunosuppressant, TNF modulator
- HALF-LIFE: 5–7 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Amiodarone, Antihistamines, Antipsychotics, Bortezomib, Calcium channel blockers, Carbamazepine, Cimetidine, Cisplatin, CNS depressants, Digoxin, Disulfiram, Docetaxel, Famotidine, Griseofulvin, Lithium, Metronidazole, Modafinil, Opioids, Paclitaxel, Penicillins, Phenytoin, Rifabutin, Rifampin, St John's Wort, Succinylcholine, Vincristine
- See adverse reactions attributed to class:
Investigated for treating COVID-19.
Thalidomide is a potent teratogen, an agent that causes congenital malformations and developmental abnormalities if introduced during gestation. Some of these teratogenic side effects of thalidomide include fetal limb growth retardation (arms, legs, hands, feet), ingrown genitalia, absence of lung, partial/total loss of hearing or sight, malformed digestive tract, heart, kidney, and stillborn infant.
FETAL RISK AND VENOUS THROMBOEMBOLIC EVENTS
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Page last updated 01/31/2024
