Contra-indicated in patients with hypersensitivity to docetaxel or polysorbate 80, or with neutrophil counts of <1500 cells/mm3.
- TRADE NAME: Taxotere (Sanofi-Aventis)
- INDICATIONS: Metastatic breast cancer, non-small cell lung cancer; with prednisone in hormone refractory prostate cancer; with cisplatin and fluorouracil for gastric adenocarcinoma and squamous cell carcinoma of the head and neck
- CLASS: Antineoplastic / anticancer agent (see also Immune checkpoint inhibitor), Taxane
- HALF-LIFE: 11–18 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Aldesleukin, Anthracyclines, Antifungals, Aprepitant, BCG Vaccine, Conivaptan, Cyclosporine, CYP3A4 inhibitors or inducers, Dasatinib, Deferasirox, Denosumab, Echinacea, Erythromycin, Itraconazole, Ketoconazole, Lapatinib, Leflunomide, Natalizumab, P-glycoprotein inhibitors or inducers, Pimecrolimus, Prednisone, Ritonavir, Sipuleucel-T, Sorafenib, St John's Wort, Tacrolimus, Thalidomide, Trastuzumab, Vaccines, Voriconazole
- See adverse reactions attributed to class:
Antineoplastic / anticancer agent (see also Immune checkpoint inhibitor)
TOXIC DEATHS, HEPATOTOXICITY, NEUTROPENIA, HYPERSENSITIVITY REACTIONS, and FLUID RETENTION
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Page last updated 02/09/2025
