Ritonavir
- TRADE NAMES: Kaletra (AbbVie); Norvir (AbbVie)
- INDICATIONS: HIV infection
- CLASS: Antiretroviral, CYP3A4 inhibitor, HIV-1 protease inhibitor
- HALF-LIFE: 3–5 hours
Abiraterone, Afatinib, Alfentanil, Alfuzosin, Alprazolam, Amiodarone, Amitriptyline, Amprenavir, Aprepitant, Astemizole, Atazanavir, Atorvastatin, Atovaquone, Atovaquone/Proguanil, Avanafil, Azithromycin, Bepridil, Boceprevir, Bosentan, Brigatinib, Buprenorphine, Bupropion, Buspirone, Cabazitaxel, Cabozantinib, Calcifediol, Carbamazepine, Ceritinib, Chlordiazepoxide, Ciclesonide, Citalopram, Clozapine, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Colchicine, Conivaptan, Copanlisib, Crizotinib, Cyclosporine, Cyproterone, Darifenacin, Dasatinib, Deferasirox, Delavirdine, Diazepam, Diclofenac, Dihydroergotamine, Docetaxel, Dronedarone, Dutasteride, Efavirenz, Eletriptan, Eluxadoline, Ergot alkaloids, Ergotamine, Erlotinib, Estazolam, Estradiol, Eszopiclone, Etravirine, Everolimus, Ezetimibe, Fentanyl, Fesoterodine, Flecainide, Flibanserin, Flurazepam, Fluticasone Propionate, Glecaprevir & Pibrentasvir, Halazepam, Indacaterol, Isavuconazonium Sulfate, Itraconazole, Ivabradine, Ixabepilone, Ketoconazole, Lapatinib, Ledipasvir & Sofosbuvir, Levomepromazine, Levothyroxine, Lomitapide, Macitentan, Maraviroc, Meloxicam, Meperidine, Meptazinol, Methylergonovine, Methysergide, Midazolam, Midostaurin, Mifepristone, Naldemedine, Nelfinavir, Neratinib, Nifedipine, Nilotinib, Olaparib, Oral Contraceptives, Osimertinib, Paclitaxel, Palbociclib, Paroxetine Hydrochloride, Pazopanib, Phenytoin, Pimozide, Piroxicam, Pitavastatin, Ponatinib, Posaconazole, Propafenone, Propoxyphene, Propranolol, Quazepam, Quinidine, Quinine, Ranolazine, Ribociclib, Rifabutin, Rifampin, Rifapentine, Rilpivirine, Rimonabant, Risperidone, Rivaroxaban, Romidepsin, Rosuvastatin, Ruxolitinib, Saquinavir, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sofosbuvir, Sofosbuvir/Velpatasvir/Voxilaprevir, Solifenacin, St John's Wort, Sunitinib, Tadalafil, Telaprevir, Telithromycin, Temsirolimus, Tenofovir Disoproxil, Ticagrelor, Tolvaptan, Trabectedin, Triazolam, Ulipristal, Vardenafil, Vemurafenib, Venetoclax, Vorapaxar, Voriconazole, Zolpidem, Zuclopenthixol
PREGNANCY CATEGORY: B
Protease inhibitors cause dyslipidemia which includes elevated triglycerides and cholesterol and redistribution of body fat centrally to produce the so-called 'protease paunch', breast enlargement, facial atrophy, and 'buffalo hump'.
Kaletra is ritonavir and lopinavir.
See also separate entry for ombitasvir/paritaprevir/ritonavir.
See full prescribing information for complete boxed warning.
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Page last updated 10/30/2018
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
