Estradiol
- TRADE NAMES: Alora (Watson); Climara (Bayer); Divigel (Upsher-Smith); Elestrin (Azur Pharma); Esclim (Women First); Estrace (Bristol-Myers Squibb, Warner Chilcott); Estraderm (Novartis); Estring (Pharmacia & Upjohn); Estrogel (Ascend); Evamist (KV Pharm); Fempatch (Pfizer); Gynodiol (Barr); Innofem (Novo Nordisk); Menostar (Bayer); Vagifem (Novo Nordisk); Vivelle (Novartis); Vivelle-Dot (Novartis)
- INDICATIONS: Menopausal symptoms, hypoestrogenism due to hypogonadism, castration or primary ovarian failure, postmenopausal osteoporosis
- CLASS: Estrogen, Hormone
- HALF-LIFE: 1.75±2.87 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Amprenavir, Anastrozole, Ascorbic Acid, Atorvastatin, Boceprevir, Carbamazepine, Chenodiol, Clarithromycin, Colesevelam, Conivaptan, Corticosteroids, CYP1A2 inducers, CYP3A4 inducers, Deferasirox, Delavirdine, Erythromycin, Folic Acid, Grapefruit Juice, Itraconazole, Ketoconazole, Lopinavir, Minocycline, Oxtriphylline, P-glycoprotein inhibitors or inducers, PEG-Interferon, Phenobarbital, Rifampin, Ritonavir, Ropinirole, Saxagliptin, Somatropin, St John's Wort, Telaprevir, Thyroid products, Tipranavir, Ursodiol
PREGNANCY CATEGORY: X
See also separate entry for estrogens.
ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER and PROBABLE DEMENTIA
See full prescribing information for complete boxed warning.
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SKIN.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
NEUROMUSCULAR/SKELETAL.
RESPIRATORY.
OTHER.
Page last updated 07/31/2023
Symbol key
Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
