Aromatic antiepileptic drugs, phenytoin, phenobarbital, carbamazepine and primidone, are a frequent cause of severe cutaneous adverse reactions. A strong genetic association between HLA-B*1502 and phenobarbital-induced Stevens-Johnson syndrome and toxic epidermal necrolysis has been shown in Han Chinese patients.
- TRADE NAMES: Alepsal; Barbilixir; Barbita; Barbital; Gardenal; Luminal (Sanofi-Aventis); Luminaletten; Phenaemal; Phenobarbitone; Solfoton
- INDICATIONS: Insomnia, seizures
- SYNONYM: phenobarbitone; phenylethylmalonylurea
- CLASS: Anticonvulsant (see also antiepileptic (anti-seizure)), Barbiturate, CYP3A4 inducer
- HALF-LIFE: 2–6 days
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Abacavir, Abiraterone, Afatinib, Alcohol, Amprenavir, Anticoagulants, Antihistamines, Apremilast, Aprepitant, Betamethasone, Bictegravir/Emtricitabine/Tenofovir Alafenamide, Boceprevir, Brompheniramine, Buclizine, Buprenorphine, Cabazitaxel, Cabozantinib, Caffeine, Calcifediol, Cenobamate, Chlorpheniramine, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Crizotinib, Darunavir, Dasatinib, Deferasirox, Delavirdine, Dexamethasone, Dicumarol, Doravirine, Doravirine/Lamiduvine/Tenofovir Disoproxil, Doxercalciferol, Dronedarone, Eliglustat, Emtricitabine/Rilpivirine/Tenofovir Alafenamide, Enzalutamide, Erlotinib, Estradiol, Ethanolamine, Ethosuximide, Etravirine, Fesoterodine, Flibanserin, Fluconazole, Flunisolide, Fosamprenavir, Gefitinib, Hydrocortisone, Imatinib, Indinavir, Influenza Vaccine, Itraconazole, Ixabepilone, Lacosamide, Lapatinib, Ledipasvir & Sofosbuvir, Lisdexamfetamine, Lopinavir, Meperidine, Methsuximide, Methylprednisolone, Midazolam, Mifepristone, Nilotinib, Ombitasvir/Paritaprevir/Ritonavir, Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir, Osilodrostat, Osilodrostat, Oxcarbazepine, Oxtriphylline, Paroxetine Hydrochloride, Perampanel, Piracetam, Pizotifen, Prednisolone, Prednisone, Propranolol, Ranolazine, Regorafenib, Rilpivirine, Riociguat, Rivaroxaban, Roflumilast, Romidepsin, Rufinamide, Simeprevir, Sodium Oxybate, Sofosbuvir, Sofosbuvir & Velpatasvir, Sofosbuvir/Velpatasvir/Voxilaprevir, Solifenacin, Sonidegib, Sorafenib, Sunitinib, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Tenofovir Alafenamide, Tezacaftor/Ivacaftor, Tiagabine, Ticagrelor, Tipranavir, Trabectedin, Triamcinolone, Ulipristal, Vandetanib, Vemurafenib, Voriconazole, Warfarin
- See adverse reactions attributed to class:
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Page last updated 11/07/2024
