Phenobarbital
- TRADE NAMES: Alepsal; Barbilixir; Barbita; Barbital; Gardenal; Luminal (Sanofi-Aventis); Luminaletten; Phenaemal; Phenobarbitone; Solfoton
- INDICATIONS: Insomnia, seizures
- SYNONYM: phenobarbitone; phenylethylmalonylurea
- CLASS: Anticonvulsant, Barbiturate, CYP3A4 inducer
- HALF-LIFE: 2–6 days
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PREGNANCY CATEGORY: D
Aromatic antiepileptic drugs, phenytoin, phenobarbital, carbamazepine and primidone, are a frequent cause of severe cutaneous adverse reactions. A strong genetic association between HLA-B*1502 and phenobarbital-induced Stevens-Johnson syndrome and toxic epidermal necrolysis has been shown in Han Chinese patients.
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Page last updated 07/31/2023
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
