Phenobarbital

BreastfeedingGeriatric
  • TRADE NAMES: Alepsal; Barbilixir; Barbita; Barbital; Gardenal; Luminal (Sanofi-Aventis); Luminaletten; Phenaemal; Phenobarbitone; Solfoton
  • INDICATIONS: Insomnia, seizures
  • SYNONYM: phenobarbitone; phenylethylmalonylurea
  • CLASS: Anticonvulsant, Barbiturate, CYP3A4 inducer
  • HALF-LIFE: 2–6 days
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Abacavir, Abiraterone, Afatinib, Alcohol, Amprenavir, Anticoagulants, Antihistamines, Apremilast, Aprepitant, Betamethasone, Bictegravir/Emtricitabine/Tenofovir Alafenamide, Boceprevir, Brompheniramine, Buclizine, Buprenorphine, Cabazitaxel, Cabozantinib, Caffeine, Calcifediol, Cenobamate, Chlorpheniramine, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Crizotinib, Darunavir, Dasatinib, Deferasirox, Delavirdine, Dexamethasone, Dicumarol, Doxercalciferol, Dronedarone, Eliglustat, Emtricitabine/Rilpivirine/Tenofovir Alafenamide, Enzalutamide, Estradiol, Ethanolamine, Ethosuximide, Etravirine, Fesoterodine, Flibanserin, Fluconazole, Flunisolide, Fosamprenavir, Gefitinib, Hydrocortisone, Imatinib, Indinavir, Influenza Vaccine, Itraconazole, Ixabepilone, Lacosamide, Lapatinib, Ledipasvir & Sofosbuvir, Lisdexamfetamine, Lopinavir, Meperidine, Methsuximide, Methylprednisolone, Midazolam, Mifepristone, Nilotinib, Ombitasvir/Paritaprevir/Ritonavir, Ombitasvir/Paritaprevir/Ritonavir, Oxcarbazepine, Oxtriphylline, Paroxetine Hydrochloride, Perampanel, Piracetam, Pizotifen, Prednisolone, Prednisone, Propranolol, Ranolazine, Regorafenib, Rilpivirine, Riociguat, Rivaroxaban, Roflumilast, Romidepsin, Rufinamide, Simeprevir, Sodium Oxybate, Sofosbuvir, Sofosbuvir & Velpatasvir, Sofosbuvir/Velpatasvir/Voxilaprevir, Solifenacin, Sonidegib, Sorafenib, Sunitinib, Telaprevir, Telithromycin, Temsirolimus, Teniposide, Tenofovir Alafenamide, Tezacaftor/Ivacaftor, Tiagabine, Ticagrelor, Tipranavir, Trabectedin, Triamcinolone, Ulipristal, Vandetanib, Vemurafenib, Voriconazole, Warfarin

PREGNANCY CATEGORY: D

Aromatic antiepileptic drugs, phenytoin, phenobarbital, carbamazepine and primidone, are a frequent cause of severe cutaneous adverse reactions. A strong genetic association between HLA-B*1502 and phenobarbital-induced Stevens-Johnson syndrome and toxic epidermal necrolysis has been shown in Han Chinese patients.

Our database has 72 adverse reactions for this drug across the following areas

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SKIN.
HAIR.
NAILS.
MUCOSAL.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
LOCAL.
NEUROMUSCULAR/SKELETAL.
OTHER.


Page last updated 03/28/2020

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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