Lisdexamfetamine drug interactions | Litt's Drug Eruption and Reaction Database

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TRADE NAME: Vyvanse (Shire)
INDICATIONS: Attention-deficit hyperactivity disorder (ADHD)
CLASS: Anti-attention deficit hyperactivity disorder (anti-ADHD), CNS stimulant, Dextroamphetamine prodrug
HALF-LIFE: 1 hour

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Acetazolamide, Ammonium chloride, Analgesics, Antacids, Antihistamines, Antihypertensives, Antipsychotics, Atomoxetine, Cannabinoids, Carbonic anhydrase inhibitors, Chlorpromazine, Epinephrine, Ethosuximide, Haloperidol, Iobenguane, Lithium, MAO inhibitors, Meperidine, Methenamine, Phenobarbital, Phenytoin, Propoxyphene, Sympathomimetics, Tricyclic antidepressants, Urinary alkalinizing agents

See adverse reactions attributed to class:
Anti-attention deficit hyperactivity disorder (anti-ADHD)

ABUSE AND DEPENDENCE

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Page last updated 12/22/2025

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<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Hospitalization possible
Life threatening
Fatal

Breast feeding

Geriatric

Pediatric