Propoxyphene drug interactions | Litt's Drug Eruption and Reaction Database

Propoxyphene comment watch save

TRADE NAMES: Algafan; Antalvic; Darvocet-N (Xanodyne); Darvon (Xanodyne); Darvon Compound (Xanodyne); Develin; Dolotard; Doloxene; Liberan; Parvon
INDICATIONS: Pain
CLASS: Opiate agonist
HALF-LIFE: 8–24 hours

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Alprazolam, Amitriptyline, Carbamazepine, Insulin Aspart, Insulin Degludec, Insulin Glargine, Insulin Glulisine, Linezolid, Lisdexamfetamine, Metoprolol, Phenelzine, Ritonavir, Safinamide, Selegiline, Warfarin
PREGNANCY: category D with prolonged use

See adverse reactions attributed to class:
Opiate agonist

Darvocet is propoxyphene and acetaminophen; Darvon Compound is propoxyphene and aspirin.

This drug has been withdrawn from the European market. Xanodyne has voluntarily removed its products from the US market. The FDA is advising healthcare professionals to stop prescribing propoxyphene to their patients.

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Page last updated 07/31/2023

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Incidence

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Seriousness

Hospitalization possible
Life threatening
Fatal

Warnings in other populations

Breast feeding

Geriatric

Pediatric