Safinamide
- TRADE NAME: Xadago (Newron)
- INDICATIONS: Adjunctive treatment to levodopa/carbidopa in patients with Parkinson's disease experiencing 'off' episodes
- CLASS: Monoamine oxidase B inhibitor
- HALF-LIFE: 20–26 hours
FDA APPROVAL DATE: 03/21/2017
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:Cyclobenzaprine, Dextromethorphan, Dopaminergic antagonists, Imatinib, Irinotecan, Isoniazid, Lapatinib, Linezolid, Meperidine, Methadone, Methylphenidate, Metoclopramide, Mitoxantrone, Other MAO inhibitors, Propoxyphene, Rosuvastatin, Serotonergic drugs, St John's Wort, Sulfasalazine, Sympathomimetics, Topotecan, Tramadol, Tricyclic or tetracyclic antidepressants
PREGNANCY CATEGORY: C
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SKIN.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
RESPIRATORY.
OTHER.
Page last updated 08/02/2021
Symbol key
Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
