Sulfasalazine
- TRADE NAMES: Azulfidine (Pfizer); Colo-Pleon; Salazopyrin; Salisulf; Saridine; SAS-500; Sulfazine; Ulcol
- INDICATIONS: Inflammatory bowel disease, ulcerative colitis, rheumatoid arthritis
- SYNONYM: salicylazosulfapyridine; salazopyrin
- CLASS: Aminosalicylate, Disease-modifying antirheumatic drug (DMARD), Sulfonamide
- HALF-LIFE: 5–10 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Cholestyramine, Methotrexate, Safinamide
PREGNANCY CATEGORY: B
Sulfasalazine is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.
Contra-indicated in patients with intestinal or urinary obstruction, or with porphyria.
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SKIN.
HAIR.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
LOCAL.
NEUROMUSCULAR/SKELETAL.
OCULAR.
RENAL.
RESPIRATORY.
OTHER.
Page last updated 02/17/2024
Symbol key
Incidence
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric