Warfarin

  • TRADE NAMES: Aldocumar; Coumadin (Bristol-Myers Squibb); Coumadine; Marevan; Waran; Warfilone
  • INDICATIONS: Thromboembolic disease, pulmonary embolism
  • CLASS: Anticoagulant, Coumarin
  • HALF-LIFE: 1.5–2.5 days (highly variable)
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Acemetacin, Amiodarone, Amobarbital, Amprenavir, Antithyroid agents, Aprepitant, Aprobarbital, Aspirin, Atazanavir, Atorvastatin, Azathioprine, Azithromycin, Barbiturates, Beclomethasone, Betamethasone, Bezafibrate, Bismuth, Bivalirudin, Boceprevir, Bosentan, Butabarbital, Capecitabine, Cefixime, Celecoxib, Ceritinib, Chondroitin, Cimetidine, Ciprofloxacin, Clarithromycin, Clofibrate, Clopidogrel, Clorazepate, Co-Trimoxazole, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Alafenamide, Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Disoproxil, Colesevelam, Cyclosporine, Danazol, Daptomycin, Darunavir, Delavirdine, Desvenlafaxine, Dexamethasone, Dexibuprofen, Dexlansoprazole, Diclofenac, Dicloxacillin, Dirithromycin, Disulfiram, Dronedarone, Duloxetine, Econazole, Efavirenz, Enzalutamide, Ergotamine, Erlotinib, Erythromycin, Eslicarbazepine, Etoricoxib, Exenatide, Fenofibrate, Fluconazole, Flunisolide, Fluoxymesterone, Fosamprenavir, Gefitinib, Gemfibrozil, Glucagon, Grapefruit Juice, Heparin, Imatinib, Influenza Vaccine, Itraconazole, Ketoconazole, Leflunomide, Lepirudin, Letermovir, Levofloxacin, Levothyroxine, Liothyronine, Liraglutide, Lomitapide, Lopinavir, Menadione, Mephobarbital, Methimazole, Methyl salicylate, Methylprednisolone, Methyltestosterone, Metronidazole, Miconazole, Mifepristone, Moricizine, Moxifloxacin, Nafcillin, Nalidixic Acid, Nandrolone, Nilutamide, Norfloxacin, Obeticholic Acid, Ofloxacin, Omeprazole, Oritavancin, Orlistat, Pantoprazole, PEG-Interferon, Penicillin G, Penicillin V, Penicillins, Pentobarbital, Phenobarbital, Phenylbutazones, Phytonadione, Piperacillin, Piroxicam, Prasugrel, Primidone, Propoxyphene, Propranolol, Propylthiouracil, Quinidine, Quinine, Rabeprazole, Resveratrol, Rifampin, Rifapentine, Rofecoxib, Romidepsin, Ropinirole, Rosuvastatin, Roxithromycin, Salicylates, Secobarbital, Simvastatin, Sitaxentan, Sorafenib, St John's Wort, Stanozolol, Sulfamethoxazole, Sulfinpyrazone, Sulfisoxazole, Sulfonamides, Sulindac, Tamsulosin, Tegafur/Gimeracil/Oteracil, Telaprevir, Telithromycin, Teriflunomide, Testosterone, Tibolone, Tigecycline, Tinidazole, Tolmetin, Tolterodine, Triamcinolone, Troleandomycin, Uracil/Tegafur, Valdecoxib, Vemurafenib, Venlafaxine, Vilazodone, Vitamin A, Vitamin E, Zafirlukast, Zileuton

PREGNANCY CATEGORY: X
category D for women with mechanical heart valves

Alternative remedies, including herbals, may potentially increase the risk of bleeding or potentiate the effects of warfarin therapy. Some of these include the following: angelica root, arnica flower, anise, asafetida, bogbean, borage seed oil, bromelain, dan-shen, devil’s claw, fenugreek, feverfew, garlic, ginger, ginkgo biloba, ginseng, horse chestnut, lovage root, meadowsweet, onion, parsley, passionflower herb, poplar, quassia, red clover, rue, turmeric and willow bark

BLEEDING RISK

See full prescribing information for complete boxed warning.

Our database has 85 adverse reactions for this drug across the following areas

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SKIN
HAIR
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
GASTROINTESTINAL/HEPATIC
GENITOURINARY
HEMATOLOGIC
NEUROMUSCULAR/SKELETAL
OCULAR
RENAL
RESPIRATORY
OTHER


Page last updated 08/06/2019

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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