Litts Drug Eruption & Reaction Database - Presented by CRC Press

... an essential tool for dermatologists and other specialists Spencer D. Hawkins, The Dermatologist


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PEG-Interferon comment watch save
BreastfeedingPediatric

  • TRADE NAMES: Pegasys; PegIntron (Schering); Sylatron (Schering)
  • INDICATIONS: Chronic hepatitis C, melanoma
  • CLASS: Immunomodulator, Interferon
  • HALF-LIFE: ~40 hours
  • CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
    ACE inhibitors, Acetaminophen, Aldesleukin, Bupivacaine, Cilostazol, Cinacalcet, CYP2C9 substrates, CYP2D6 substrates, Delavirdine, Duloxetine, Estradiol, Fesoterodine, Fingolimod, Fluoxetine, Indinavir, Melphalan, Methadone, Methylnaltrexone, Pantoprazole, Pegloticase, Ribavirin, Sildenafil, Tapentadol, Telbivudine, Theophylline, Theophylline derivatives, Tiotropium, Trimethoprim, Voriconazole, Warfarin, Zidovudine
  • PREGNANCY: pregnancy category will be X when used in combination with ribavirin
  • See adverse reactions attributed to class:

    Immunomodulator

    Interferon

PEG-interferon is commonly administered with ribavirin and many of the reactions listed below are in combination therapy with this drug.

Contra-indicated in patients with known hypersensitivity reactions, such as urticaria, angioedema, bronchoconstriction, anaphylaxis, Stevens-Johnson syndrome, and toxic epidermal necrolysis to interferon alpha or any other product component; or with autoimmune hepatitis.

RISK OF SERIOUS DISORDERS AND RIBAVIRIN-ASSOCIATED EFFECTS and DEPRESSION AND OTHER NEUROPSYCHIATRIC DISORDERS

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Page last updated 02/16/2024

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Incidence

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Seriousness

Hospitalization possible
Life threatening
Fatal

Warnings in other populations

BreastfeedingBreast feeding

GeriatricGeriatric

PediatricPediatric

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