PEG-Interferon

BreastfeedingPediatric
  • TRADE NAMES: Pegasys; PegIntron (Schering); Sylatron (Schering)
  • INDICATIONS: Chronic hepatitis C, melanoma
  • CLASS: Immunomodulator, Interferon
  • HALF-LIFE: ~40 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

ACE inhibitors, Acetaminophen, Aldesleukin, Bupivacaine, Cilostazol, Cinacalcet, CYP2C9 substrates, CYP2D6 substrates, Delavirdine, Duloxetine, Estradiol, Fesoterodine, Fingolimod, Fluoxetine, Indinavir, Melphalan, Methadone, Methylnaltrexone, Pantoprazole, Pegloticase, Ribavirin, Sildenafil, Tapentadol, Telbivudine, Theophylline, Theophylline derivatives, Tiotropium, Trimethoprim, Voriconazole, Warfarin, Zidovudine

PREGNANCY CATEGORY: C
pregnancy category will be X when used in combination with ribavirin

PEG-interferon is commonly administered with ribavirin and many of the reactions listed below are in combination therapy with this drug.

Contra-indicated in patients with known hypersensitivity reactions, such as urticaria, angioedema, bronchoconstriction, anaphylaxis, Stevens-Johnson syndrome, and toxic epidermal necrolysis to interferon alpha or any other product component; or with autoimmune hepatitis.

RISK OF SERIOUS DISORDERS AND RIBAVIRIN-ASSOCIATED EFFECTS and DEPRESSION AND OTHER NEUROPSYCHIATRIC DISORDERS


See full prescribing information for complete boxed warning.

Our database has 152 adverse reactions for this drug across the following areas

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SKIN.
HAIR.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
LOCAL.
NEUROMUSCULAR/SKELETAL.
OCULAR.
OTIC.
RENAL.
RESPIRATORY.
OTHER.


Page last updated 09/16/2019

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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