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- TRADE NAMES: Adofen; Apo-Fluoxetine; Dom-Fluoxetine; Fluctin; Fluctine; Fludac; Fluoxac; Fluoxeren; Fluxil; Fontex; Prozac (Lilly); Sarafem (Warner Chilcott); Symbyax (Lilly)
- INDICATIONS: Depression, obsessive-compulsive disorder
- CLASS: Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
- HALF-LIFE: 2–3 days
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alprazolam, Amoxapine, Amphetamines, Astemizole, Clarithromycin, Clopidogrel, Clozapine, Desipramine, Deutetrabenazine, Dexibuprofen, Dextroamphetamine, Diethylpropion, Droperidol, Duloxetine, Erythromycin, Gilteritinib, Haloperidol, Iloperidone, Imipramine, Insulin Aspart, Insulin Degludec, Insulin Glargine, Insulin Glulisine, Isocarboxazid, Linezolid, Lithium, MAO inhibitors, Mazindol, Meperidine, Methamphetamine, Midazolam, Moclobemide, Nifedipine, Nortriptyline, Olanzapine, Oliceridine, PEG-Interferon, Phendimetrazine, Phenelzine, Phentermine, Phenylpropanolamine, Phenytoin, Pimozide, Propranolol, Pseudoephedrine, Rasagiline, Risperidone, Selegiline, Serotonin agonists, Sibutramine, St John's Wort, Sumatriptan, Sympathomimetics, Tramadol, Tranylcypromine, Trazodone, Tricyclic antidepressants, Troleandomycin, Tryptophan, Valbenazine, Vortioxetine, Zolmitriptan
- See adverse reactions attributed to class:
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants for Major Depressive Disorder (MDD) and other psychiatric disorders.
Sarafem is not approved for use in pediatric patients with MDD and obsessive compulsive disorder. Symbyax is not approved for use in children and adolescents.
Symbyax is fluoxetine and olanzapine.
SUICIDAL THOUGHTS AND BEHAVIORS
See full prescribing information for complete boxed warning.
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Click on the DRUG REVIEW ARTICLE tab (above) to see a review of fluoxetine in combination with olanzapine in the Taylor & Francis journal Expert Opinion on Drug Safety.
(Note that non-subscribers to the journal will only be able to see an abstract of the article.)
Page last updated 04/06/2025
