Fluoxetine drug interactions | Litt's Drug Eruption and Reaction Database

Fluoxetine comment watch save

TRADE NAMES: Adofen; Apo-Fluoxetine; Dom-Fluoxetine; Fluctin; Fluctine; Fludac; Fluoxac; Fluoxeren; Fluxil; Fontex; Prozac (Lilly); Sarafem (Warner Chilcott); Symbyax (Lilly)
INDICATIONS: Depression, obsessive-compulsive disorder
CLASS: Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
HALF-LIFE: 2–3 days

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alprazolam, Amoxapine, Amphetamines, Astemizole, Clarithromycin, Clopidogrel, Clozapine, Desipramine, Deutetrabenazine, Dexibuprofen, Dextroamphetamine, Diethylpropion, Droperidol, Duloxetine, Erythromycin, Gilteritinib, Haloperidol, Iloperidone, Imipramine, Insulin Aspart, Insulin Degludec, Insulin Glargine, Insulin Glulisine, Isocarboxazid, Linezolid, Lithium, MAO inhibitors, Mazindol, Meperidine, Methamphetamine, Midazolam, Moclobemide, Nifedipine, Nortriptyline, Olanzapine, Oliceridine, PEG-Interferon, Phendimetrazine, Phenelzine, Phentermine, Phenylpropanolamine, Phenytoin, Pimozide, Propranolol, Pseudoephedrine, Rasagiline, Risperidone, Selegiline, Serotonin agonists, Sibutramine, St John's Wort, Sumatriptan, Sympathomimetics, Tramadol, Tranylcypromine, Trazodone, Tricyclic antidepressants, Troleandomycin, Tryptophan, Valbenazine, Vortioxetine, Zolmitriptan

See adverse reactions attributed to class:
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)

Increased risk of suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants for Major Depressive Disorder (MDD) and other psychiatric disorders.
Sarafem is not approved for use in pediatric patients with MDD and obsessive compulsive disorder. Symbyax is not approved for use in children and adolescents.

Symbyax is fluoxetine and olanzapine.

SUICIDAL THOUGHTS AND BEHAVIORS

See full prescribing information for complete boxed warning.

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DRUG REVIEW ARTICLE

Click on the DRUG REVIEW ARTICLE tab (above) to see a review of fluoxetine in combination with olanzapine in the Taylor & Francis journal Expert Opinion on Drug Safety.

(Note that non-subscribers to the journal will only be able to see an abstract of the article.)

Page last updated 04/06/2025

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Incidence

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Seriousness

Hospitalization possible
Life threatening
Fatal

Warnings in other populations

Breast feeding

Geriatric

Pediatric