Can cause DRESS and other serious skin reactions.
Symbyax is olanzapine and fluoxetine; Zypraxa Relprevv is olanzapine pamoate.
- TRADE NAMES: Symbyax (Lilly); Zyprexa (Lilly); Zyprexa Relprevv (Lilly)
- INDICATIONS: Schizophrenia, bipolar I disorder
- CLASS: Antipsychotic, Antipsychotic, atypical, Muscarinic antagonist
- HALF-LIFE: 21–54 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Antihypertensive agents, Carbamazepine, Ciprofloxacin, CNS acting drugs, Diazepam, Dopamine agonists, Eszopiclone, Fluoxetine, Fluvoxamine, Insulin Degludec, Insulin Detemir, Insulin Glargine, Levodopa, Lithium, Metoclopramide, Tetrabenazine, Valproic Acid
- See adverse reactions attributed to class:
INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS
Zyprexa Relprevv: POST-INJECTION DELIRIUM/SEDATION SYNDROME
See full prescribing information for complete boxed warning.
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Click on the DRUG REVIEW ARTICLE tab (above) to see a review of olanzapine in the Taylor & Francis journal Expert Opinion on Drug Safety. See also a separate review of olanzapine in combination with fluoxetine in the drug profile for fluoxetine.
(Note that non-subscribers to the journal will only be able to see an abstract of the article.)
Page last updated 06/14/2025
