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- TRADE NAMES: Ciflox; Ciloxan Ophthalmic (Alcon); Cimogal; Ciplox; Cipro (Bayer); Ciprobay Uro; Cipromycin; Ciproxin (Bayer); Italnik; Kenzoflex; Uniflox
- INDICATIONS: Various infections caused by susceptible organisms, inhalational anthrax (post exposure)
- CLASS: Antibiotic, Antibiotic; fluoroquinolone, Antibiotic; quinolone, Antimicrobial, CYP1A2 inhibitor, CYP3A4 inhibitor
- HALF-LIFE: 4 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Agomelatine, Aminophylline, Amiodarone, Amitriptyline, Antacids, Antineoplastics, Arsenic, Artemether/Lumefantrine, BCG Vaccine, Bendamustine, Bepridil, Bismuth, Bismuth subsalicylate, Bretylium, Calcium salts, Citalopram, Clopidogrel, Clozapine, Corticosteroids, Cyclosporine, Dairy products, Dasatinib, Degarelix, Didanosine, Disopyramide, Dolasetron, Duloxetine, Dutasteride, Eluxadoline, Erlotinib, Erythromycin, Flibanserin, Insulin, Lanthanum, Lapatinib, Levofloxacin, Lumateperone, Magnesium salts, Meptazinol, Methotrexate, Methylxanthines, Mifepristone, Moxifloxacin, Mycophenolate, Neratinib, NSAIDs, Olanzapine, Olaparib, Opiod analgesics, Oral iron, Oxtriphylline, P-glycoprotein inhibitors, Pazopanib, Pentoxifylline, Phenothiazines, Phenytoin, Pirfenidone, Probenecid, Procainamide, Propranolol, QT prolonging agents, Quinapril, Quinidine, Rasagiline, Ropinirole, Ropivacaine, Sevelamer, Sotalol, St John's Wort, Strontium Ranelate, Sucralfate, Sulfonylureas, Telavancin, Telithromycin, Tizanidine, Tricyclic antidepressants, Typhoid Vaccine, Ubrogepant, Venetoclax, Vitamin K antagonists, Voriconazole, Vorinostat, Warfarin, Zinc, Ziprasidone, Zolmitriptan
- See adverse reactions attributed to class:
Fluoroquinolones are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants.
Fluoroquinolones may exacerbate muscle weakness in persons with myasthenia gravis.
Ciprofloxacin is chemically related to nalidixic acid.
SERIOUS ADVERSE REACTIONS INCLUDING TENDINITIS, TENDON RUPTURE, PERIPHERAL NEUROPATHY, CENTRIAL NERVOUS SYSTEM EFFECTS and EXACERBATION OF MYASTHENIA GRAVIS
See full prescribing information for complete boxed warning.
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Page last updated 09/14/2024
