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- TRADE NAMES: Accupril (Pfizer); Accuprin; Accupro (Pfizer); Accuretic (Pfizer); Acuitel; Acupril; Asig; Korec; Quinazil
- INDICATIONS: Hypertension; heart failure
- CLASS: Angiotensin-converting enzyme (ACE) inhibitor, Antihypertensive, Vasodilator
- HALF-LIFE: 2 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Aldesleukin, Allopurinol, Alpha blockers, Alprostadil, Amifostine, Amiloride, Angiotensin II receptor antagonists, Antacids, Antidiabetics, Antihypertensives, Antipsychotics, Anxiolytics and hypnotics, Aprotinin, Azathioprine, Baclofen, Beta blockers, Calcium channel blockers, Chlortetracycline, Ciprofloxacin, Clonidine, Corticosteroids, Cyclosporine, Demeclocycline, Diazoxide, Diuretics, Doxycycline, Eplerenone, Estrogens, Everolimus, Gemifloxacin, General anesthetics, Gold & Gold Compounds, Heparins, Hydralazine, Insulin, Levodopa, Lithium, Lymecycline, MAO inhibitors, Metformin, Methyldopa, Methylphenidate, Minocycline, Minoxidil, Moxifloxacin, Moxisylyte, Moxonidine, Nitrates, Nitroprusside, NSAIDs, Ofloxacin, Oxytetracycline, Pentoxifylline, Phosphodiesterase 5 inhibitors, Potassium salts, Prostacyclin analogues, Quinine, Quinolones, Rituximab, Salicylates, Sirolimus, Spironolactone, Sulfonylureas, Temsirolimus, Tetracycline, Tetracyclines, Tigecycline, Tizanidine, Tolvaptan, Triamterene, Trimethoprim - PREGNANCY: category C in first trimester; category D in second and third trimesters
- See adverse reactions attributed to class:
Contra-indicated in patients with a history of angioedema related to previous treatment with an ACE inhibitor.
FETAL TOXICITY
WHEN USED IN PREGNANCY DURING THE SECOND AND THIRD TRIMESTERS, ACE INHIBITORS CAN CAUSE INJURY AND EVEN DEATH TO THE DEVELOPING FETUS. WHEN PREGNANCY IS DETECTED, QUINAPRIL SHOULD BE DISCONTINUED AS SOON AS POSSIBLE.
See full prescribing information for complete boxed warning.
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Page last updated 08/21/2024
