Gemifloxacin

BreastfeedingGeriatricPediatric
  • TRADE NAME: Factive (LG Life Sciences)
  • INDICATIONS: Infections due to various microorganisms
  • CLASS: Antibiotic; fluoroquinolone
  • HALF-LIFE: 4–12 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Antacids, BCG Vaccine, Calcium salts, Corticosteroids, Didanosine, Dong Quai, Insulin, Iron salts, Magnesium salts, Mycophenolate, NSAIDs, Probenecid, Quinapril, Sevelamer, St John's Wort, Sucralfate, Sulfonylureas, Typhoid Vaccine, Vitamin K antagonists, Zinc

PREGNANCY CATEGORY: C

NOTE

Fluoroquinolones are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants.

Fluoroquinolones may exacerbate muscle weakness in persons with myasthenia gravis.

The incidence of rash increases significantly when duration of therapy exceeds seven days, reaching 7.4% at 14 days.

BLACK BOX WARNING
SERIOUS ADVERSE REACTIONS INCLUDING TENDINITIS, TENDON RUPTURE, PERIPHERAL NEUROPATHY, CENTRIAL NERVOUS SYSTEM EFFECTS and EXACERBATION OF MYASTHENIA GRAVIS

See full prescribing information for complete boxed warning.

Our database has 57 adverse reactions for this drug across the following areas

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SKIN.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
GENITOURINARY.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
RESPIRATORY.
OTHER.


Page last updated 09/03/2019

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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