Trimethoprim
- TRADE NAMES: Abaprim; Alprim; Bactin; Bactrim (Women First); Idotrim; Ipral; Lidaprim; Methoprim; Monotrim; Polytrim; Primosept; Primsol; Septra (Monarch); Syraprim; Tiempe; Trimopan; Triprim; Unitrim
- INDICATIONS: Various urinary tract infections caused by susceptible organisms, acute otitis media in children, acute and chronic bronchitis
- CLASS: Antibiotic, Antimicrobial
- HALF-LIFE: 8–10 hours
ACE inhibitors, Amantadine, Angiotensin II receptor antagonists, Antidiabetics, Azathioprine, Benazepril, Captopril, Carvedilol, Cilazapril, Conivaptan, Coumarins, Cyclosporine, CYP2C8 substrates, CYP2C9 inhibitors, CYP3A4 inducers, Dapsone, Deferasirox, Digoxin, Dofetilide, Enalapril, Eplerenone, Fosinopril, Irbesartan, Lamivudine, Leucovorin, Levoleucovorin, Lisinopril, Memantine, Mercaptopurine, Metformin, Methotrexate, Olmesartan, Oral typhoid vaccine, PEG-Interferon, Phenytoin, Pioglitazone, Pralatrexate, Procainamide, Pyrimethamine, Quinapril, Ramipril, Repaglinide, Rifampin, Sulfonylureas, Trandolapril
PREGNANCY CATEGORY: C
Although trimethoprim has been known to elicit occasional adverse reactions by itself, it is most commonly used in conjunction with sulfamethoxazole (co-trimoxazole - see separate entry).
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Page last updated 07/31/2023
Symbol key
Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
