Trimethoprim

Breastfeeding
  • TRADE NAMES: Abaprim; Alprim; Bactin; Bactrim (Women First); Idotrim; Ipral; Lidaprim; Methoprim; Monotrim; Polytrim; Primosept; Primsol; Septra (Monarch); Syraprim; Tiempe; Trimopan; Triprim; Unitrim
  • INDICATIONS: Various urinary tract infections caused by susceptible organisms, acute otitis media in children, acute and chronic bronchitis
  • CLASS: Antibiotic, Antimicrobial
  • HALF-LIFE: 8–10 hours
CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

ACE inhibitors, Amantadine, Angiotensin II receptor antagonists, Antidiabetics, Azathioprine, Benazepril, Captopril, Carvedilol, Cilazapril, Conivaptan, Coumarins, Cyclosporine, CYP2C8 substrates, CYP2C9 inhibitors, CYP3A4 inducers, Dapsone, Deferasirox, Digoxin, Dofetilide, Enalapril, Eplerenone, Fosinopril, Irbesartan, Lamivudine, Leucovorin, Levoleucovorin, Lisinopril, Memantine, Mercaptopurine, Metformin, Methotrexate, Olmesartan, Oral typhoid vaccine, PEG-Interferon, Phenytoin, Pioglitazone, Pralatrexate, Procainamide, Pyrimethamine, Quinapril, Ramipril, Repaglinide, Rifampin, Sulfonylureas, Trandolapril

PREGNANCY CATEGORY: C

Although trimethoprim has been known to elicit occasional adverse reactions by itself, it is most commonly used in conjunction with sulfamethoxazole (co-trimoxazole - see separate entry).

Our database has 40 adverse reactions for this drug across the following areas

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SKIN.
MUCOSAL.
CARDIOVASCULAR.
CENTRAL NERVOUS SYSTEM.
ENDOCRINE/METABOLIC.
GASTROINTESTINAL/HEPATIC.
HEMATOLOGIC.
NEUROMUSCULAR/SKELETAL.
OCULAR.
RENAL.
RESPIRATORY.
OTHER.


Page last updated 08/01/2022

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric
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