Lisinopril
- TRADE NAMES: Acerbon; Alapril; Carace; Coric; Prinil; Prinivil (Merck); Prinzide (Merck); Tensopril; Vivatec; Zestoretic (AstraZeneca); Zestril (AstraZeneca)
- INDICATIONS: Hypertension; as adjunctive therapy in the management of heart failure; short-term treatment following myocardial infarction in hemodynamically stable patients
- CLASS: Angiotensin-converting enzyme (ACE) inhibitor
- HALF-LIFE: 12 hours
Alcohol, Aldesleukin, Allopurinol, Alpha blockers, Alprostadil, Amifostine, Amiloride, Angiotensin II receptor antagonists, Antacids, Antidiabetics, Antihypertensives, Antipsychotics, Anxiolytics and hypnotics, Aprotinin, Azathioprine, Baclofen, Beta blockers, Calcium channel blockers, Clonidine, Corticosteroids, Cyclosporine, Diazoxide, Diuretics, Eplerenone, Estrogens, Everolimus, General anesthetics, Gold & Gold Compounds, Heparins, Hydralazine, Hypotensives, Insulin, Levodopa, Liraglutide, Lithium, MAO inhibitors, Metformin, Methyldopa, Methylphenidate, Minoxidil, Moxisylyte, Moxonidine, Nitrates, Nitroprusside, NSAIDs, Pentoxifylline, Phosphodiesterase 5 inhibitors, Potassium salts, Prostacyclin analogues, Rituximab, Salicylates, Sirolimus, Spironolactone, Sulfonylureas, Temsirolimus, Tizanidine, Tolvaptan, Triamterene, Trimethoprim, Yohimbine
PREGNANCY CATEGORY: D
category C in first trimester; category D in second and third trimesters
Prinzide and Zestoretic are lisinopril and hydrochlorothiazide.
Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.
Contra-indicated in patients with a history of angioedema related to previous treatment with an ACE inhibitor and in patients with hereditary or idiopathic angioedema.
See full prescribing information for complete boxed warning.
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Page last updated 02/13/2020
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
