Metformin
- TRADE NAMES: Apo-Metformin; Avandamet (GSK); Diabex; Diaformin; Diformin; Fortamet (Andrx); Gen-Metformin; Glucomet; Glucophage (Merck Serono); Glucovance (Merck Serono); Invokamet (Janssen); Janumet (Merck Sharpe & Dohme); Metaglip; Metforal; Metomin; Novo-Metformin; Riomet; Synjardy (Boehringer Ingelheim); Xigduo XR (AstraZeneca)
- INDICATIONS: Diabetes
- CLASS: Antidiabetic, Biguanide, Hypoglycemic (antihyperglycemic) agent
- HALF-LIFE: 6 hours
ACE inhibitors, Acetazolamide, Alcohol, Amiloride, Anabolic steroids, Beta blockers, Bictegravir/Emtricitabine/Tenofovir Alafenamide, Calcium channel blockers, Captopril, Cephalexin, Cilazapril, Cimetidine, Corticosteroids, Diazoxide, Dichlorphenamide, Digoxin, Disopyramide, Diuretics, Enalapril, Estrogens, Fosinopril, Iodinated contrast agents, Isoniazid, Ketotifen, Lanreotide, Lisinopril, Luteinizing hormone releasing hormone analogs, MAO inhibitors, Morphine, Nicotinic acid, Octreotide, Oral Contraceptives, Pegvisomant, Phenothiazines, Phenytoin, Procainamide, Progestogens, Quinapril, Quinidine, Quinine, Ramipril, Ranitidine, Risdiplam, Somatropin, Sotorasib, Sympathomimetics, Testosterone, Thiazides, Thyroid products, Topiramate, Trandolapril, Triamterene, Trilaciclib, Trimethoprim, Trospium, Tucatinib, Vancomycin, Zonisamide
PREGNANCY CATEGORY: B
Lactic acidosis is a rare, but serious, metabolic complication that can occur due to metformin accumulation.
Avandamet is metformin and rosiglitazone; Glucovance is metformin and glyburide; Invokamet is metformin and canagliflozin; Janumet is metformin and sitagliptin; Synjardy is metformin and empagliflozin; Xigduo XR is metformin and dapagliflozin.
See full prescribing information for complete boxed warning.
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Page last updated 11/02/2023
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric
