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- TRADE NAMES: Amprace; Apo-Enalapril; Enaladil; Enapren; Glioten; Innovace (Merck Sharpe & Dohme); Lexxel (AstraZeneca); Pres; Renitec; Reniten; Teczem (Sanofi-Aventis); Vaseretic (Valeant); Vasotec (Valeant); Xanef
- INDICATIONS: Hypertension, symptomatic congestive heart failure, asymptomatic left ventricular dysfunction
- CLASS: Angiotensin-converting enzyme (ACE) inhibitor, Antihypertensive, Vasodilator
- HALF-LIFE: 11 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Aldesleukin, Allopurinol, Alpha blockers, Alprostadil, Amifostine, Amiloride, Angiotensin II receptor antagonists, Antacids, Antidiabetics, Antihypertensives, Antipsychotics, Anxiolytics and hypnotics, Aprotinin, Azathioprine, Baclofen, Beta blockers, Calcium channel blockers, Clonidine, Conivaptan, Corticosteroids, Cyclosporine, CYP3A4 inducers, Deferasirox, Diazoxide, Diuretics, Eplerenone, Estrogens, Everolimus, General anesthetics, Gold & Gold Compounds, Grapefruit Juice, Heparins, Hydralazine, Hypotensives, Insulin, Levodopa, Lithium, MAO inhibitors, Metformin, Methyldopa, Methylphenidate, Minoxidil, Moxisylyte, Moxonidine, Nitrates, Nitroprusside, NSAIDs, Pentoxifylline, Phosphodiesterase 5 inhibitors, Potassium salts, Prostacyclin analogues, Quinine, Rituximab, Salicylates, Sirolimus, Spironolactone, Sulfonylureas, Tadalafil, Temsirolimus, Tizanidine, Tolvaptan, Triamterene, Trimethoprim - PREGNANCY: category C in first trimester; category D in second and third trimesters
- See adverse reactions attributed to class:
Lexxel is enalapril and felodipine; Teczem is enalapril and diltiazem; Vaseretic is enalapril and hydrochlorothiazide.
Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.
Contra-indicated in patients with a history of angioedema with or without previous ACE inhibitor treatment.
FETAL TOXICITY
See full prescribing information for complete boxed warning.
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Page last updated 11/18/2023
