Lexxel is enalapril and felodipine; Teczem is enalapril and diltiazem; Vaseretic is enalapril and hydrochlorothiazide.

Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.

Contra-indicated in patients with a history of angioedema with or without previous ACE inhibitor treatment.

FETAL TOXICITY

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Page last updated 02/06/2025

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Incidence

<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Seriousness

Hospitalization possible
Life threatening
Fatal

Warnings in other populations

BreastfeedingBreast feeding

GeriatricGeriatric

PediatricPediatric