HLA-B*5801 confers a risk of allopurinol-induced serious skin reactions like SJS/TEN and DRESS. Should be seriously considered in patients of south Asian ancestry.
Duzallo is allopurinol and lesinurad (see separate entry).
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- TRADE NAMES: Allo 300; Allo-Puren; Alloprin; Atisuril; Bleminol; Caplenal; Duzallo (AstraZeneca); Hamarin; Novo-Purol; Purinol; Unizuric; Zyloprim (Prometheus); Zyloric
- INDICATIONS: Gouty arthritis
- CLASS: Purine analog, Uricosuric, Xanthine oxidase inhibitor
- HALF-LIFE: <3 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Acenocoumarol, Amoxicillin, Ampicillin, Ampicillin/Sulbactam, Azathioprine, Benazepril, Capecitabine, Captopril, Cilazapril, Cyclopenthiazide, Dicumarol, Enalapril, Fosinopril, Imidapril, Lisinopril, Mercaptopurine, Pantoprazole, Quinapril, Ramipril, Trandolapril, Uracil/Tegafur, Vidarabine, Zofenopril
- See adverse reactions attributed to class:
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Page last updated 02/27/2025
