Patients receiving concomitant capecitabine and oral coumarin-derivative anticoagulants such as warfarin and phenprocoumon should have their anticoagulant response (INR or prothrombin time) monitored frequently in order to adjust the anticoagulant dose accordingly. Altered coagulation parameters and/or bleeding, including death, have been reported during concomitant use.

Contra-indicated in patients with severe renal impairment or with known hypersensitivity to fluorouracil.

Capecitabine is a prodrug of 5-fluorouracil.

CapeOX (also called XELOX) is a combination of capecitabine and oxaliplatin.

See full prescribing information for complete boxed warning.