- Trade Names: Antrex; Citrec; Folinic Acid; Lederfolin; Leucovorin; Refolinin; Rescufolin; Rescuvolin
- Indications: Overdose of methotrexate; in combination with fluorouracil in the palliative treatment of patients with colorectal cancer. Advanced pancreatic cancer (in combination with oxaliplatin/irinotecan/fluorouracil (FOLFIRINOX or FOLFOXIRI)). Used in combination with fluorouracil and irinotecan (FOLFIRI) for treatment of advanced-stage and metastatic colorectal cancer. Used in combination with fluorouracil and oxaliplatin (FOLFOX; mFOLFOX6) for treatment of colorectal cancer.
- Synonym: citrovorum factor; folinic acid
- Class: Antidote, Chemotherapy modulating agent, Folate analogue
- Half-life: 15 minutes
- Clinically important, potentially hazardous interactions with:
Capecitabine, Glucarpidase, Trimethoprim
- See adverse reactions attributed to class:
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Page last updated 08/20/2025
