- TRADE NAMES: Antrex; Citrec; Folinic Acid; Lederfolin; Leucovorin; Refolinin; Rescufolin; Rescuvolin
- INDICATIONS: Overdose of methotrexate; in combination with fluorouracil in the palliative treatment of patients with colorectal cancer. Advanced pancreatic cancer (in combination with oxaliplatin/irinotecan/fluorouracil (FOLFIRINOX or FOLFOXIRI)). Used in combination with fluorouracil and irinotecan (FOLFIRI) for treatment of advanced-stage and metastatic colorectal cancer. Used in combination with fluorouracil and oxaliplatin (FOLFOX; mFOLFOX6) for treatment of colorectal cancer.
- SYNONYM: citrovorum factor; folinic acid
- CLASS: Antidote, Chemotherapy modulating agent, Folate analogue
- HALF-LIFE: 15 minutes
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Capecitabine, Glucarpidase, Trimethoprim
- See adverse reactions attributed to class:
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Page last updated 12/22/2023
